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Literature summary for 3.1.26.4 extracted from

  • White, R.; Saxty, B.; Large, J.; Kettleborough, C.A.; Jackson, A.P.
    Identification of small-molecule inhibitors of the ribonuclease H2 enzyme (2013), J. Biomol. Screen., 18, 610-620.
    View publication on PubMed
Search for more literature for 3.1.26.4

Inhibitors

Inhibitors Comment Organism Structure
2-(2,3-dimethylphenyl)-6-fluoro-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(2,5-dimethylphenyl)-6-fluoro-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(4,6-dimethyl-3-oxo-1,2-benzothiazol-2(3H)-yl)-N-propylacetamide
-
 Homo sapiens
2-(4-chlorophenyl)-6-fluoro-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(6-fluoro-3-oxo-1,2-benzothiazol-2(3H)-yl)-N-(4-methylphenyl)acetamide
-
 Homo sapiens
2-phenyl-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(cyclopentylcarbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide
-
 Homo sapiens
6-(naphthalen-2-yl)-3-(pyridin-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
-
 Homo sapiens
6-fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
6-fluoro-2-(4-methylphenyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
N-(5-benzyl-1,3,4-thiadiazol-2-yl)-2-ethylhexanamide
-
 Homo sapiens
N-benzyl-2-(6-fluoro-3-oxo-1,2-benzothiazol-2(3H)-yl)acetamide
-
 Homo sapiens
N-cyclopentyl-2-(4,6-dimethyl-3-oxo[1,2]thiazolo[5,4-b]pyridin-2(3H)-yl)acetamide
-
 Homo sapiens
N-cyclopropyl-1-methyl-3-oxo-1,3-dihydro-2,1-benzothiazole-5-sulfonamide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RNA-DNA hybrid + H2O Homo sapiens
-
 ribonucleotide 5'-phosphomonoester
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RNA-DNA hybrid + H2O
-
 Homo sapiens ribonucleotide 5'-phosphomonoester
-
 ?

Synonyms

Synonyms Comment Organism
RNase H2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00001
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens 6-fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one
0.00002
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens 2-phenyl-1,2-benzothiazol-3(2H)-one
0.00005
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens 2-(6-fluoro-3-oxo-1,2-benzothiazol-2(3H)-yl)-N-(4-methylphenyl)acetamide
0.00019
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens 2-(2,3-dimethylphenyl)-6-fluoro-1,2-benzothiazol-3(2H)-one
0.0002
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens 6-fluoro-2-(4-methylphenyl)-1,2-benzothiazol-3(2H)-one
0.0004
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens N-cyclopropyl-1-methyl-3-oxo-1,3-dihydro-2,1-benzothiazole-5-sulfonamide
0.00045
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens 2-(2,5-dimethylphenyl)-6-fluoro-1,2-benzothiazol-3(2H)-one
0.00048
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens N-benzyl-2-(6-fluoro-3-oxo-1,2-benzothiazol-2(3H)-yl)acetamide
0.0005
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens 2-(4-chlorophenyl)-6-fluoro-1,2-benzothiazol-3(2H)-one
0.0019
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens 2-[(cyclopentylcarbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide
0.00332
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens N-cyclopentyl-2-(4,6-dimethyl-3-oxo[1,2]thiazolo[5,4-b]pyridin-2(3H)-yl)acetamide
0.0054
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens N-(5-benzyl-1,3,4-thiadiazol-2-yl)-2-ethylhexanamide
0.0064
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens 6-(naphthalen-2-yl)-3-(pyridin-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
0.00833
-
 60 mM KCl, 50 mM Tris-HCl, pH 8.0, 10 mM MgCl2, 0.01% (w/v) bovine serum albumin, 0.01% (v/v) Triton X-100, at 20°C Homo sapiens 2-(4,6-dimethyl-3-oxo-1,2-benzothiazol-2(3H)-yl)-N-propylacetamide