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Literature summary for 3.1.26.4 extracted from

  • Lu, Z.; Hou, J.; Wang, Y.; Liu, J.
    Involvement of Ser94 in RNase HIII from Chlamydophila pneumoniae in the recognition of a single ribonucleotide misincorporated into double-stranded DNA (2012), Biochim. Biophys. Acta, 1824, 859-865.
    View publication on PubMed
Search for more literature for 3.1.26.4

Protein Variants

Protein Variants Comment Organism
S94V the mutation decreases the RNase H activity 3-6fold Chlamydia pneumoniae

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required Chlamydia pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RNA-DNA hybrid + H2O Chlamydia pneumoniae
-
 ribonucleotide 5'-phosphomonoester + ?
-
 ?
RNA-DNA hybrid + H2O Chlamydia pneumoniae AR39
-
 ribonucleotide 5'-phosphomonoester + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Chlamydia pneumoniae
-
-
-
Chlamydia pneumoniae AR39
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme can cleave a DNA-rN1-DNA/DNA substrate (rN1, one ribonucleotide) in vitro, e.g. a RNA-DNA hybrid consisting of CGTCCCaCCGTGC and aucagaaaaAGAGCG strands (capital letters and small bold letters represent DNA and RNA, respectively) Chlamydia pneumoniae ?
-
 ?
additional information the enzyme can cleave a DNA-rN1-DNA/DNA substrate (rN1, one ribonucleotide) in vitro, e.g. a RNA-DNA hybrid consisting of CGTCCCaCCGTGC and aucagaaaaAGAGCG strands (capital letters and small bold letters represent DNA and RNA, respectively) Chlamydia pneumoniae AR39 ?
-
 ?
RNA-DNA hybrid + H2O
-
 Chlamydia pneumoniae ribonucleotide 5'-phosphomonoester + ?
-
 ?
RNA-DNA hybrid + H2O
-
 Chlamydia pneumoniae AR39 ribonucleotide 5'-phosphomonoester + ?
-
 ?

Synonyms

Synonyms Comment Organism
RNase HIII
-
 Chlamydia pneumoniae