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Literature summary for 3.1.26.4 extracted from

  • Lima, W.F.; Rose, J.B.; Nichols, J.G.; Wu, H.; Migawa, M.T.; Wyrzykiewicz, T.K.; Vasquez, G.; Swayze, E.E.; Crooke, S.T.
    The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis (2007), Mol. Pharmacol., 71, 73-82.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information chimeric substrates containing 2'-methoxyethyl nucleotides inhibit human RNase H1 activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-2'-methoxyethoxy RNA hybrid chimeric substrates containing a central DNA region with flanking northern-biased 2'-methoxyethyl nucleotides hybridized to complementary RNA, enhanced cleavage rates are observed for the eastern-biased 2'-ara-fluorothymidine and bulge inducing N-methylthymidine modifications positioned at the 5'-DNA/3'-MOE junction as well as the southern-biased 2'-methylthiothymidine and conformationally flexible tetrafluoroindole modifications positioned at the 5'-MOE/3'-DNA junction, overview Homo sapiens ?
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?
additional information substrate specificity of RNase H1 with modifies heteroduplexes, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
RNase H1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
24
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens