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Literature summary for 3.1.26.3 extracted from

  • Deltcheva, E.; Chylinski, K.; Sharma, C.M.; Gonzales, K.; Chao, Y.; Pirzada, Z.A.; Eckert, M.R.; Vogel, J.; Charpentier, E.
    CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III (2011), Nature, 471, 602-607.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptococcus pyogenes maturation of repeat/spacer-derived short crRNAs by RNase III and the CRISPR-associated Csn1 protein. The co-processed tracrRNA and pre-crRNA carry short 3' overhangs reminiscent of cleavage by the endoribonuclease RNase III ?
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?
additional information Streptococcus pyogenes SF370 maturation of repeat/spacer-derived short crRNAs by RNase III and the CRISPR-associated Csn1 protein. The co-processed tracrRNA and pre-crRNA carry short 3' overhangs reminiscent of cleavage by the endoribonuclease RNase III ?
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?

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes
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M1 serotype
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Streptococcus pyogenes SF370
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M1 serotype
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information maturation of repeat/spacer-derived short crRNAs by RNase III and the CRISPR-associated Csn1 protein. The co-processed tracrRNA and pre-crRNA carry short 3' overhangs reminiscent of cleavage by the endoribonuclease RNase III Streptococcus pyogenes ?
-
?
additional information maturation of repeat/spacer-derived short crRNAs by RNase III and the CRISPR-associated Csn1 protein. The co-processed tracrRNA and pre-crRNA carry short 3' overhangs reminiscent of cleavage by the endoribonuclease RNase III Streptococcus pyogenes SF370 ?
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?

Synonyms

Synonyms Comment Organism
RNase III
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Streptococcus pyogenes

General Information

General Information Comment Organism
physiological function tracrRNA directs the maturation of repeat/spacer-derived short crRNAs by the activities of the widely conserved endogenous RNase III and the CRISPR-associated Csn1 protein. The maturation of crRNAs represents a key event in CRISPR activation, all components are essential to protect Streptococcus pyogenes against prophage-derived DNA. The co-processed tracrRNA and pre-crRNA carry short 3' overhangs reminiscent of cleavage by the endoribonuclease RNase III or the related eukaryotic Dicer and Drosha enzymes Streptococcus pyogenes