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Literature summary for 3.1.26.3 extracted from

  • Knight, S.W.; Bass, B.L.
    A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans (2001), Science, 293, 2269-2271.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
construction of transgenic lines by microinjection of a DNA vector encoding the enzyme and the green fluorescent protein Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
additional information dcr-1 gene N-terminal deletion and null mutants show defective RNAi and are steril, overview Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dsRNA + H2O Caenorhabditis elegans cleavage to short RNA pieces ?
-
?
additional information Caenorhabditis elegans enzyme is essential, and is involved in RNA interference, i.e. RNAi, a post-transcriptional gene-silencing phenomenon, and germ line development ?
-
?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
gene dcr-1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dsRNA + H2O cleavage to short RNA pieces Caenorhabditis elegans ?
-
?
additional information enzyme is essential, and is involved in RNA interference, i.e. RNAi, a post-transcriptional gene-silencing phenomenon, and germ line development Caenorhabditis elegans ?
-
?

Synonyms

Synonyms Comment Organism
DCR-1
-
Caenorhabditis elegans
Dicer-1
-
Caenorhabditis elegans
RNase III
-
Caenorhabditis elegans