Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | isozyme ELAC2 | Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene ELAC2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
mt-pre-tRNAArg + H2O | - |
Homo sapiens | mt-tRNAArg + 3'-leader of tRNA | - |
? | |
mt-pre-tRNAGlu + H2O | - |
Homo sapiens | mt-tRNAGlu + 3'-leader of tRNA | - |
? | |
mt-pre-tRNAGly + H2O | - |
Homo sapiens | mt-tRNAGly + 3'-leader of tRNA | - |
? | |
mt-pre-tRNALeu + H2O | - |
Homo sapiens | mt-tRNALeu + 3'-leader of tRNA | - |
? | |
mt-pre-tRNALys + H2O | - |
Homo sapiens | mt-tRNALys + 3'-leader of tRNA | - |
? | |
mt-pre-tRNAVal + H2O | - |
Homo sapiens | mt-tRNAVal + 3'-leader of tRNA | - |
? |
General Information | Comment | Organism |
---|---|---|
malfunction | silencing of the gene MRPP1 encoding a subunit of the enzyme leads to inhibition of both 5' and 3' processing | Homo sapiens |
physiological function | accurate tRNA processing in crucial for mitochondrial genom expression. ELAC2 functions as a mitochondrial tRNase, it cleaves preferentially molecules already processed by mtRNase P | Homo sapiens |