Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.21.1 extracted from

  • Kaneko, Y.; Takeshita, H.; Mogi, K.; Nakajima, T.; Yasuda, T.; Itoi, M.; Kuwano, H.; Kishi, K.
    Molecular, biochemical and immunological analyses of canine pancreatic DNase I (2003), J. Biochem., 134, 711-718.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, expression in COS-7 cells Canis lupus familiaris

Inhibitors

Inhibitors Comment Organism Structure
EDTA complete inhibition at 20 mM Canis lupus familiaris
EGTA complete inhibition at 5 mM Canis lupus familiaris

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates Canis lupus familiaris
Mg2+ activates Canis lupus familiaris
Mn2+ activates Canis lupus familiaris
additional information divalent cations are absolutely required for activity Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Canis lupus familiaris phylogenetic analysis ?
-
?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris Q767J3
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein 1 potential N-glycosylation site Canis lupus familiaris

Purification (Commentary)

Purification (Comment) Organism
260fold from pancreas, to homogeneity Canis lupus familiaris

Reaction

Reaction Comment Organism Reaction ID
endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products preference for double-stranded DNA Canis lupus familiaris

Source Tissue

Source Tissue Comment Organism Textmining
kidney low activity Canis lupus familiaris
-
large intestine low activity Canis lupus familiaris
-
liver low activity Canis lupus familiaris
-
additional information no activity in spleen, parotid gland, lung, heart, cerebellum, and cerebrum Canis lupus familiaris
-
pancreas highest enzyme activity and expression Canis lupus familiaris
-
small intestine low activity Canis lupus familiaris
-
stomach
-
Canis lupus familiaris
-
sublingual gland low activity Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
purified enzyme Canis lupus familiaris

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + H2O
-
Canis lupus familiaris 5'-phosphodinucleotide + 5'-phosphooligonucleotide
-
?
additional information phylogenetic analysis Canis lupus familiaris ?
-
?

Synonyms

Synonyms Comment Organism
DNase I
-
Canis lupus familiaris
pancreatic DNase I
-
Canis lupus familiaris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Canis lupus familiaris