Literature summary for 3.1.2.6 extracted from

Park, H.; Nam, S.; Lee, J.K.; Yoon, C.N.; Mannervik, B.; Benkovic, S.J.; Kim, H.
Design and evolution of new catalytic activity with an existing protein scaffold (2006), Science, 311, 535-538.

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Protein Variants

Protein Variants	Comment	Organism
additional information	introduction of beta-lactamase activity into the alphabeta/betaalpha metallohydrolase scaffold of glyoxalase II. The resulting enzyme, evMBL8 (evolved metallo beta-lactamase 8), completely loses its original activity and, instead, catalyzes the hydrolysis of, thus increasing resistance to Escherichia coli growth on cefotaxime by a factor of about 100	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16775	-	-

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Release 2023.1 (January 2023)