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Literature summary for 3.1.2.6 extracted from

  • Rulli, A.; Antognelli, C.; Prezzi, E.; Baldracchini, F.; Piva, F.; Giovannini, E.; Talesa, V.
    A possible regulatory role of 17beta-estradiol and tamoxifen on glyoxalase I and glyoxalase II genes expression in MCF7 and BT20 human breast cancer cells (2006), Breast Cancer Res. Treat., 96, 187-196.
    View publication on PubMed

Application

Application Comment Organism
medicine cultivation of estrogen receptor positive MCF7 and estrogen receptor neagtive BT20 human breast cancer cells in presence of tamoxifen and 17beta-estradiol. Estradiol causes up to 60% decrease in enzyme mRNA in MCF7 cells, while there are no significant changes in presence of tamoxifen. In BT20 cells, tamoxifen causes a reduction of enzyme expression up to 85%. Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16775
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Source Tissue

Source Tissue Comment Organism Textmining
BT-20 cell human breast cancer cell, estrogen-receptor negative Homo sapiens
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MCF-7 cell human breast cancer cell, estrogen-receptor positive Homo sapiens
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