Application | Comment | Organism |
---|---|---|
medicine | cultivation of estrogen receptor positive MCF7 and estrogen receptor neagtive BT20 human breast cancer cells in presence of tamoxifen and 17beta-estradiol. Estradiol causes up to 60% decrease in enzyme mRNA in MCF7 cells, while there are no significant changes in presence of tamoxifen. In BT20 cells, tamoxifen causes a reduction of enzyme expression up to 85%. | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16775 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BT-20 cell | human breast cancer cell, estrogen-receptor negative | Homo sapiens | - |
MCF-7 cell | human breast cancer cell, estrogen-receptor positive | Homo sapiens | - |