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Literature summary for 3.1.2.6 extracted from

  • vander Jagt, D.L.
    The glyoxalase system (1989), Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York, 3, 597-641.
No PubMed abstract available
Search for more literature for 3.1.2.6

Inhibitors

Inhibitors Comment Organism Structure
2,4,6-Trinitrobenzenesulfonate
-
 Homo sapiens
2,4,6-Trinitrobenzenesulfonate
-
 Rattus norvegicus
diethyldicarbonate
-
 Rattus norvegicus
methylene blue photoinactivation Rattus norvegicus
Phenylglyoxal
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.016
-
 S-mandeloylglutathione enzyme from liver Homo sapiens
0.07
-
 S-glycolylglutathione enzyme from liver Homo sapiens
0.109
-
 S-glyceroylglutathione enzyme from liver Homo sapiens
0.153
-
 S-formylglutathione enzyme from liver Homo sapiens
0.19
-
 S-Lactoylglutathione enzyme from liver Homo sapiens
0.2
-
 S-succinylglutathione enzyme from liver Homo sapiens
0.213
-
 S-propionylglutathione enzyme from liver Homo sapiens
0.266
-
 S-acetylglutathione enzyme from liver Homo sapiens
0.295
-
 S-Acetoacetylglutathione enzyme from liver Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mesocricetus auratus
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Oxidation Stability

Oxidation Stability Organism
photoinactivation by methylene blue Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain
-
 Rattus norvegicus
-
Ehrlich ascites carcinoma cell
-
 Mus musculus
-
erythrocyte
-
 Homo sapiens
-
erythrocyte
-
 Rattus norvegicus
-
fibroadenoma cell fibroadenoma mammae cells Homo sapiens
-
glioblastoma cell glioblastoma multiform cells Homo sapiens
-
hepatoma cell Morris hepatoma cells 5123S Rattus norvegicus
-
hepatoma cell Kirkman-Robbins hepatoma Mesocricetus auratus
-
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
muscle
-
 Homo sapiens
-
S-180 cell
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
773
-
-
 Rattus norvegicus
822
-
-
 Homo sapiens
920
-
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lactoylglutathione + H2O
-
 Mus musculus D-lactate + glutathione
-
 ?
lactoylglutathione + H2O
-
 Homo sapiens D-lactate + glutathione
-
 ?
lactoylglutathione + H2O
-
 Rattus norvegicus D-lactate + glutathione
-
 ?
S-acetoacetylglutathione + H2O
-
 Homo sapiens acetoacetate + glutathione
-
 ?
S-acetoacetylglutathione + H2O
-
 Rattus norvegicus acetoacetate + glutathione
-
 ?
S-acetylglutathione + H2O
-
 Homo sapiens acetate + glutathione
-
 ?
S-acetylglutathione + H2O
-
 Rattus norvegicus acetate + glutathione
-
 ?
S-formylglutathione + H2O
-
 Homo sapiens formate + glutathione
-
 ?
S-formylglutathione + H2O
-
 Rattus norvegicus formate + glutathione
-
 ?
S-glyceroylglutathione + H2O
-
 Homo sapiens glycerate + glutathione
-
 ?
S-glycerylglutathione + H2O
-
 Homo sapiens glycerate + glutathione
-
 ?
S-glycoloylglutathione + H2O
-
 Homo sapiens glycolate + glutathione
-
 ?
S-lactoylglutathione + H2O
-
 Homo sapiens D-lactate + glutathione
-
 ?
S-mandeloylglutathione + H2O
-
 Homo sapiens mandelate + glutathione
-
 ?
S-propionylglutathione + H2O
-
 Homo sapiens propionate + glutathione
-
 ?
S-propionylglutathione + H2O
-
 Rattus norvegicus propionate + glutathione
-
 ?
S-succinylglutathione + H2O
-
 Homo sapiens succinate + glutathione
-
 ?
S-succinylglutathione + H2O
-
 Rattus norvegicus succinate + glutathione
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8 7.5
-
 Homo sapiens