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Literature summary for 3.1.2.6 extracted from
- Glutathione thiol esterases (1989), Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York, 3, 767-804.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glutathione | - |
Homo sapiens |  |
| glutathione | - |
Saccharomyces cerevisiae | |
| methylglyoxal-glutathione hemimercaptal | - |
Bos taurus | |
| methylglyoxal-glutathione hemimercaptal | - |
Homo sapiens | |
| methylglyoxal-glutathione hemimercaptal | - |
Mus musculus | |
| N,S-(dicarbobenzoxy)glutathione | - |
Rattus norvegicus | |
| N-acetyl-S-(p-bromobenzyl)glutathione | - |
Bos taurus | |
| N-acetyl-S-(p-bromobenzyl)glutathione | - |
Homo sapiens | |
| N-acetyl-S-(p-bromobenzyl)glutathione | - |
Rattus norvegicus | |
| N-benzoyl-S-(p-bromobenzyl)glutathione | - |
Rattus norvegicus | |
| N-benzyloxycarbonyl-S-(p-bromobenzyl)glutathione | - |
Rattus norvegicus | |
| S-(p-Azidophenacyl)-glutathione | - |
Bos taurus | |
| S-(p-bromobenzyl)glutathione | - |
Bos taurus | |
| S-(p-chlorophenacyl)glutathione | - |
Rattus norvegicus | |
| S-benzyloxycarbonylglutathione | - |
Bos taurus | |
| S-benzyloxycarbonylglutathione | - |
Rattus norvegicus | |
| S-m-nitrobenzyloxycarbonylglutathione | - |
Bos taurus | |
| S-m-nitrobenzyloxycarbonylglutathione | - |
Rattus norvegicus | |
| S-o-nitrobenzyloxycarbonylglutathione | - |
Bos taurus | |
| S-o-nitrobenzyloxycarbonylglutathione | - |
Rattus norvegicus | |
| S-p-nitrobenzyloxycarbonylglutathione | - |
Bos taurus | |
| S-p-nitrobenzyloxycarbonylglutathione | - |
Homo sapiens | |
| S-p-nitrobenzyloxycarbonylglutathione | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Homo sapiens | |
| additional information | - |
additional information | - |
Saccharomyces cerevisiae | |
| 0.014 | - |
S-mandeloylglutathione | enzyme from erythrocytes | Rattus norvegicus | |
| 0.015 | - |
S-mandeloylglutathione | enzyme from brain | Homo sapiens | |
| 0.016 | - |
S-mandeloylglutathione | enzyme from liver | Homo sapiens | |
| 0.07 | - |
S-glycolylglutathione | enzyme from liver | Homo sapiens | |
| 0.109 | - |
S-glyceroylglutathione | enzyme from liver | Homo sapiens | |
| 0.153 | - |
S-formylglutathione | enzyme from liver | Homo sapiens | |
| 0.18 | - |
S-Lactoylglutathione | enzyme from erythrocytes | Rattus norvegicus | |
| 0.19 | - |
S-Lactoylglutathione | enzyme from liver | Homo sapiens | |
| 0.2 | - |
S-succinylglutathione | enzyme from liver | Homo sapiens | |
| 0.21 | - |
S-Lactoylglutathione | enzyme from liver | Rattus norvegicus | |
| 0.213 | - |
S-propionylglutathione | enzyme from liver | Homo sapiens | |
| 0.266 | - |
S-acetylglutathione | enzyme from liver | Homo sapiens | |
| 0.27 | - |
S-D-lactoylglutathione | enzyme from liver | Mus musculus | |
| 0.295 | - |
S-Acetoacetylglutathione | enzyme from liver | Homo sapiens | |
| 0.304 | - |
S-Lactoylglutathione | enzyme from brain | Homo sapiens | |
| 0.325 | - |
S-Lactoylglutathione | enzyme from calf brain | Bos taurus | |
| 1.16 | - |
S-glycolylglutathione | brain | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 21000 | - |
gel filtration | Homo sapiens |
| 21000 | - |
gel filtration | Rattus norvegicus |
| 21900 | - |
erythrocytes, gel filtration | Rattus norvegicus |
| 22500 | - |
x * 22500, bovine liver, SDS-PAGE | Bos taurus |
| 22900 | - |
gel filtration | Homo sapiens |
| 23000 | - |
calf brain, gel filtration | Bos taurus |
| 24000 | - |
- |
Homo sapiens |
| 24000 | - |
gel filtration | Rattus norvegicus |
| 29500 | - |
1 * 29500, SDS-PAGE | Mus musculus |
| 30000 | - |
x * 30000, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lactoylglutathione + H2O | - |
Mus musculus | D-lactate + glutathione | - |
? | |
| lactoylglutathione + H2O | - |
Homo sapiens | D-lactate + glutathione | - |
? | |
| lactoylglutathione + H2O | - |
Rattus norvegicus | D-lactate + glutathione | - |
? | |
| lactoylglutathione + H2O | - |
Saccharomyces cerevisiae | D-lactate + glutathione | - |
? | |
| lactoylglutathione + H2O | - |
Bos taurus | D-lactate + glutathione | - |
? | |
| S-acetoacetylglutathione + H2O | - |
Homo sapiens | acetoacetate + glutathione | - |
? | |
| S-acetoacetylglutathione + H2O | - |
Rattus norvegicus | acetoacetate + glutathione | - |
? | |
| S-acetoacetylglutathione + H2O | - |
Bos taurus | acetoacetate + glutathione | - |
? | |
| S-acetylglutathione + H2O | - |
Homo sapiens | acetate + glutathione | - |
? | |
| S-acetylglutathione + H2O | - |
Rattus norvegicus | acetate + glutathione | - |
? | |
| S-acetylglutathione + H2O | - |
Bos taurus | acetate + glutathione | - |
? | |
| S-D-lactoylglutathione + H2O | - |
Mus musculus | D-lactate + glutathione | - |
? | |
| S-formylglutathione + H2O | - |
Homo sapiens | formate + glutathione | - |
? | |
| S-formylglutathione + H2O | - |
Rattus norvegicus | formate + glutathione | - |
? | |
| S-glyceroylglutathione + H2O | - |
Homo sapiens | glycerate + glutathione | - |
? | |
| S-glycerylglutathione + H2O | - |
Homo sapiens | glycerate + glutathione | - |
? | |
| S-glycoloylglutathione + H2O | - |
Homo sapiens | glycolate + glutathione | - |
? | |
| S-lactoylglutathione + H2O | - |
Homo sapiens | D-lactate + glutathione | - |
? | |
| S-mandeloylglutathione + H2O | - |
Homo sapiens | mandelate + glutathione | - |
? | |
| S-mandeloylglutathione + H2O | - |
Rattus norvegicus | mandelate + glutathione | - |
? | |
| S-mandeloylglutathione + H2O | - |
Saccharomyces cerevisiae | mandelate + glutathione | - |
? | |
| S-propionylglutathione + H2O | - |
Homo sapiens | propionate + glutathione | - |
? | |
| S-propionylglutathione + H2O | - |
Rattus norvegicus | propionate + glutathione | - |
? | |
| S-succinylglutathione + H2O | - |
Homo sapiens | succinate + glutathione | - |
? | |
| S-succinylglutathione + H2O | - |
Rattus norvegicus | succinate + glutathione | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | - |
Homo sapiens |
| ? | - |
Saccharomyces cerevisiae |
| ? | x * 30000, SDS-PAGE | Rattus norvegicus |
| ? | x * 22500, bovine liver, SDS-PAGE | Bos taurus |
| monomer | - |
Homo sapiens |
| monomer | - |
Saccharomyces cerevisiae |
| monomer | 1 * 29500, SDS-PAGE | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | 7.5 | - |
Homo sapiens |
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