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Literature summary for 3.1.2.2 extracted from

  • Hunt, M.C.; Nousiainen, S.E.; Huttunen, M.K.; Orii, K.E.; Svensson, L.T.; Alexson, S.E.
    Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism (1999), J. Biol. Chem., 274, 34317-34326.
    View publication on PubMed
Search for more literature for 3.1.2.2

Cloned(Commentary)

Cloned (Comment) Organism
genes CTE-I, MTE-I, PTE-Ia and PTE-Ib, DNA and amino acid sequence determination and analysis, promotor cloning, genes possess targeting sequences for subcellular compartment localization, genes are organized in a narrow cluster on chromosome 12, expression of CTE-I in HepG2 cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isozyme CTE-I Mus musculus 5829
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mitochondrion isozyme MTE-I Mus musculus 5739
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peroxisome isozymes PTE-Ia and PTE-Ib Mus musculus 5777
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Organism

Organism UniProt Comment Textmining
Mus musculus O55137 genes CTE-I, MTE-I, PTE-Ia and PTE-Ib with different subcellular localization and corresponding targeting sequence, phylogenetic study
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Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland strong expression of MTE-I, expression of CTE-I, PTE-Ib, and PTE-Ia Mus musculus
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brain major isozyme is CTE-I, poor expression of MTE-I, expression of PTE-Ia, no expression of PTE-Ib Mus musculus
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brown adipose tissue strong expression of MTE-I, expression of CTE-I, PTE-Ib, and PTE-Ia Mus musculus
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heart strong expression of MTE-I, expression of CTE-I and PTE-Ia, no expression of PTE-Ib Mus musculus
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intestine weak expression of MTE-I, expression of CTE-I, PTE-Ib, and PTE-Ia Mus musculus
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kidney major isozyme is CTE-I, strong expression of MTE-I, expression of PTE-Ia and PTE-Ib Mus musculus
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liver major isozyme is CTE-I, only weak expression of PTE-Ia, expression of PTE-Ib, no expression of MTE-I Mus musculus
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lung major isozyme is CTE-I, strong expression of MTE-I, expression of PTE-Ia, no expression of PTE-Ib Mus musculus
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muscle strong expression of MTE-I, only weak expression of CTE-I, expression of PTE-Ia, no expression of PTE-Ib Mus musculus
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spleen strong expression of MTE-I, expression of CTE-I and PTE-Ia, no expression of PTE-Ib Mus musculus
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testis major isozyme is CTE-I, poor expression of MTE-I, expression of PTE-Ia, no expression of PTE-Ib Mus musculus
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white adipose tissue strong expression of MTE-I, expression of CTE-I, PTE-Ib, and PTE-Ia Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + H2O
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 Mus musculus CoA + palmitate
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 ?

Synonyms

Synonyms Comment Organism
acyl-CoA thioesterase
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 Mus musculus
CTE-I
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 Mus musculus
long-chain acyl-CoA thioesterase
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 Mus musculus
MTE-I
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 Mus musculus
PTE-Ia
-
 Mus musculus
PTE-Ib
-
 Mus musculus