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Literature summary for 3.1.2.2 extracted from

  • Cohen, G.B.; Rangan, V.S.; Chen, B.K.; Smith, S.; Baltimore, D.
    The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation (2000), J. Biol. Chem., 275, 23097-23105.
    View publication on PubMed
Search for more literature for 3.1.2.2

Cloned(Commentary)

Cloned (Comment) Organism
expression as His-tagged enzyme in Escherichia coli and as GST-fusion protein in bacteria Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome thioesterase II Homo sapiens 5777
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 x * 35000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens no sufficient evidence that acyl-CoA is also the likely substrate in vivo ?
-
 ?
additional information Homo sapiens enzyme binds tightly and specifically to HIV-1 Nef protein, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 thioesterase II
-

Purification (Commentary)

Purification (Comment) Organism
recombinant as His-tagged or GST-fusion protein from bacteria Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
T-cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hexadecanoyl-CoA + H2O
-
 Homo sapiens CoA + hexadecanoate
-
 ?
additional information no sufficient evidence that acyl-CoA is also the likely substrate in vivo Homo sapiens ?
-
 ?
additional information enzyme binds tightly and specifically to HIV-1 Nef protein, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 35000, SDS-PAGE Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens