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Literature summary for 3.1.2.2 extracted from
- Involvement of the peroxisome proliferator-activated receptor a in regulating long-chain acyl-CoA thioesterases (2000), J. Lipid Res., 41, 814-823.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Clofibrate | isozymes CTE-I and MTE-I are induced, induction is completely dependent on PPARalpha | Mus musculus |  |
| Clofibrate | induction of all 4 isozymes, mediated through a strictly peroxisome proliferator-activated receptor alpha, PPARalpha, function in gene regulation | Mus musculus | |
| additional information | fat fasting rapidly induces all isozymes, rapidly reversible | Mus musculus | |
| peroxisome proliferator-activated receptor alpha | induction of the isozymes in the liver | Mus musculus | |
| PPARalpha | internal receptor protein essential for effect of stimulating compounds | Mus musculus | |
| PPARalpha | gene expression inducing and regulatory role, mediates the stimulation by clofibrate | Mus musculus | |
| PPARalpha | i.e. peroxisome proliferator-activated receptor alpha | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | PPARalpha-null mice are not stimulated by clofibrate | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | isozyme CTE I | Mus musculus | 5829 | - |
| cytosol | isozyme CTE-I, diurnal regulation and regulation by fat content of the diet | Mus musculus | 5829 | - |
| mitochondrion | isozyme MTE I | Mus musculus | 5739 | - |
| mitochondrion | isozyme MTE-I | Mus musculus | 5739 | - |
| peroxisome | isozymes PTE-Ia and PTE-Ib | Mus musculus | 5777 | - |
| peroxisome | isozmes PTE-Ia and PTE-Ib | Mus musculus | 5777 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + H2O | Mus musculus | involved in fatty acid metabolism | CoA + a carboxylate | - |
? | |
| additional information | Mus musculus | enzyme regulation | ? | - |
? | |
| additional information | Mus musculus | isozyme CTE-I: diurnal regulation and regulation by fat content of the diet | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
isozymes: cytosolic CTE-I, mitochondrial MTE-I | - |
| Mus musculus | - |
isozymes peroxisomal PTE-Ia and PTE-Ib | - |
| Mus musculus | - |
4 peroxisome proliferator-induced genes, isozymes CTE-I, MTE-I, PTE-Ia, and PTE-Ib | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + H2O | - |
Mus musculus | CoA + a carboxylate | - |
? | |
| acyl-CoA + H2O | involved in fatty acid metabolism | Mus musculus | CoA + a carboxylate | - |
? | |
| additional information | enzyme regulation | Mus musculus | ? | - |
? | |
| additional information | isozyme CTE-I: diurnal regulation and regulation by fat content of the diet | Mus musculus | ? | - |
? | |
| palmitoyl-CoA + H2O | - |
Mus musculus | CoA + palmitate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CTE-I | - |
Mus musculus |
| long-chain acyl-CoA thioesterase | - |
Mus musculus |
| MTE-I | - |
Mus musculus |
| PTE-Ia | - |
Mus musculus |
| PTE-Ib | - |
Mus musculus |
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Release 2023.1 (January 2023)
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