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Literature summary for 3.1.2.2 extracted from

  • Garras, A.; Elholm, M.; Sleboda, J.; Froyland, L.; Osmundsen, H.; Berge, R.K.
    On the effects of thia fatty acid analogs on hydrolases involved in the degradation of metabolizable and non-metabolizable acyl-CoA esters (1997), Xenobiotica, 27, 781-799.
    View publication on PubMed
Search for more literature for 3.1.2.2

Activating Compound

Activating Compound Comment Organism Structure
(tetradecylsulfanyl)acetic acid stimulates palmitoyl-CoA, tetradecylthioacetyl-CoA and tetradecylthiopropionyl-CoA hydrolase activities in cytosol, mitochondrion and peroxisome, overview Rattus norvegicus
3-(tetradecylsulfanyl)propanoic acid stimulates palmitoyl-CoA, tetradecylthioacetyl-CoA and tetradecylthiopropionyl-CoA hydrolase activities in cytosol, mitochondrion and peroxisome, overview Rattus norvegicus
additional information no stimulation by tetradecylthiopropionate Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2,2'-(decane-1,10-diyldisulfanediyl)diacetic acid palmitoyl-CoA hydrolase activity, L-fraction and peroxisomes, especially of 3-thia fatty acids treated rats Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
lysosome
-
 Rattus norvegicus 5764
-
microsome
-
 Rattus norvegicus
-
-
mitochondrion
-
 Rattus norvegicus 5739
-
additional information substrate specificities in different subcellular fractions Rattus norvegicus
-
-
peroxisome
-
 Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hexadecanoyl-CoA + H2O Rattus norvegicus i.e. palmitoyl-CoA CoA + hexadecanoate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver of rats treated with 3-thia fatty acids, i.e. tetradecylthioacetic acid and 3-dithiacarboxylic acid Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activities in different subcellular fractions with different substrates after induction with 3-thia fatty acids, overview Rattus norvegicus
0.039
-
 post-nuclear fraction, substrate tetradecylthiopropionyl-CoA Rattus norvegicus
0.044
-
 post-nuclear fraction, substrate palmitoyl-CoA Rattus norvegicus
0.057
-
 post-nuclear fraction, substrate tetradecylthioacetyl-CoA Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + H2O
-
 Rattus norvegicus CoA + a carboxylate
-
 ?
hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Rattus norvegicus CoA + hexadecanoate
-
 ?
tetradecylthioacetyl-CoA + H2O best substrate Rattus norvegicus CoA + tetradecylthioacetate
-
 ?
tetradecylthiopropionyl-CoA + H2O
-
 Rattus norvegicus CoA + tetradecylthiopropionate
-
 ?