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Literature summary for 3.1.13.1 extracted from

  • Charpentier, X.; Faucher, S.P.; Kalachikov, S.; Shuman, H.A.
    Loss of RNase R induces competence development in Legionella pneumophila (2008), J. Bacteriol., 190, 8126-8136.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
D275A is stable and produced in amounts similar to those seen for the wild-type enzyme, but it cannot repress competence Legionella pneumophila
D283R is stable and produced in amounts similar to those seen for the wild-type enzyme, but it cannot repress competence Legionella pneumophila

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Legionella pneumophila at optimal (37°C) or elevated (42°C) growth temperatures, the loss of RNase R in the RNase R mutant has no major consequence on bacterial growth and has a moderate impact on normal gene regulation. At lower temperatures (25°C or 30°C), the loss of RNase R has a significant impact on bacterial growth and results in the accumulation of structured RNA degradation products. Concurrently, gene regulation is affected and specifically results in an increased expression of the competence regulon. Loss of the exoribonuclease activity of RNase R is sufficient to induce competence development, a genetically programmed process normally triggered as a response to environmental stimuli. The temperature-dependent expression of competence genes in the rnr mutant is independent of previously identified competence regulators. The rnr mutant is competent for genetic transformation. RNase R is dispensable for the intracellular multiplication of Legionella pneumophila in both human and protozoan hosts. A physiological role of RNase R is to eliminate structured RNA molecules that are stabilized by low temperature, which in turn may affect regulatory networks, compromising adaptation to cold and thus resulting in decreased viability ?
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?
additional information Legionella pneumophila JR32 at optimal (37°C) or elevated (42°C) growth temperatures, the loss of RNase R in the RNase R mutant has no major consequence on bacterial growth and has a moderate impact on normal gene regulation. At lower temperatures (25°C or 30°C), the loss of RNase R has a significant impact on bacterial growth and results in the accumulation of structured RNA degradation products. Concurrently, gene regulation is affected and specifically results in an increased expression of the competence regulon. Loss of the exoribonuclease activity of RNase R is sufficient to induce competence development, a genetically programmed process normally triggered as a response to environmental stimuli. The temperature-dependent expression of competence genes in the rnr mutant is independent of previously identified competence regulators. The rnr mutant is competent for genetic transformation. RNase R is dispensable for the intracellular multiplication of Legionella pneumophila in both human and protozoan hosts. A physiological role of RNase R is to eliminate structured RNA molecules that are stabilized by low temperature, which in turn may affect regulatory networks, compromising adaptation to cold and thus resulting in decreased viability ?
-
?

Organism

Organism UniProt Comment Textmining
Legionella pneumophila
-
-
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Legionella pneumophila JR32
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information at optimal (37°C) or elevated (42°C) growth temperatures, the loss of RNase R in the RNase R mutant has no major consequence on bacterial growth and has a moderate impact on normal gene regulation. At lower temperatures (25°C or 30°C), the loss of RNase R has a significant impact on bacterial growth and results in the accumulation of structured RNA degradation products. Concurrently, gene regulation is affected and specifically results in an increased expression of the competence regulon. Loss of the exoribonuclease activity of RNase R is sufficient to induce competence development, a genetically programmed process normally triggered as a response to environmental stimuli. The temperature-dependent expression of competence genes in the rnr mutant is independent of previously identified competence regulators. The rnr mutant is competent for genetic transformation. RNase R is dispensable for the intracellular multiplication of Legionella pneumophila in both human and protozoan hosts. A physiological role of RNase R is to eliminate structured RNA molecules that are stabilized by low temperature, which in turn may affect regulatory networks, compromising adaptation to cold and thus resulting in decreased viability Legionella pneumophila ?
-
?
additional information at optimal (37°C) or elevated (42°C) growth temperatures, the loss of RNase R in the RNase R mutant has no major consequence on bacterial growth and has a moderate impact on normal gene regulation. At lower temperatures (25°C or 30°C), the loss of RNase R has a significant impact on bacterial growth and results in the accumulation of structured RNA degradation products. Concurrently, gene regulation is affected and specifically results in an increased expression of the competence regulon. Loss of the exoribonuclease activity of RNase R is sufficient to induce competence development, a genetically programmed process normally triggered as a response to environmental stimuli. The temperature-dependent expression of competence genes in the rnr mutant is independent of previously identified competence regulators. The rnr mutant is competent for genetic transformation. RNase R is dispensable for the intracellular multiplication of Legionella pneumophila in both human and protozoan hosts. A physiological role of RNase R is to eliminate structured RNA molecules that are stabilized by low temperature, which in turn may affect regulatory networks, compromising adaptation to cold and thus resulting in decreased viability Legionella pneumophila JR32 ?
-
?

Synonyms

Synonyms Comment Organism
RNase R
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Legionella pneumophila