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Literature summary for 3.1.11.5 extracted from

  • Handa, N.; Kowalczykowski, S.C.
    A RecA mutant, RecA(730), suppresses the recombination deficiency of the RecBC(1004)D-chi* interaction in vitro and in vivo (2007), J. Mol. Biol., 365, 1314-1325.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information the recombination deficiency of the RecBC1004D-chi interaction can be overcome by the enhanced ability of RecA730 to assemble on single-stranded DNA in vitro and in vivo Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RecBCD enzyme is a multifunctional heterotrimeric complex that possesses processive helicase and exonuclease activities. Upon encountering the DNA regulatory sequence, chi, the enzymatic properties of RecBCD enzyme are altered. Its helicase activity is reduced, the 3'-5' nuclease activity is attenuated, the 5'-3' nuclease activity is up-regulated, and it manifests an ability to load RecA protein onto single-stranded DNA. The net result of these changes is the production of a highly recombinogenic structure known as the presynaptic filament Escherichia coli ?
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