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Literature summary for 3.1.1.8 extracted from

  • Rozengart, E.; Basova, N.
    Activatory effect of substrates on the cholinesterase catalysis (2010), Dokl. Biochem. Biophys., 430, 7-10.
    View publication on PubMed
Search for more literature for 3.1.1.8

Activating Compound

Activating Compound Comment Organism Structure
2,6-dichlorophenolindophenyl acetate exhibits an activatory effect at acid pH values Equus caballus
indophenyl acetate exhibits an activatory effect at acid pH values Equus caballus
additional information at pH 5.5, phenylacetate exhibits no activatory effect within a broad concentration range (0.5-100 mM) Equus caballus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Equus caballus
-
 choline + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Equus caballus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Equus caballus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,6-dichlorophenolindophenyl acetate + H2O
-
 Equus caballus ?
-
 ?
acetylcholine + H2O
-
 Equus caballus choline + acetate
-
 ?
indophenyl acetate + H2O
-
 Equus caballus ?
-
 ?
phenyl acetate + H2O
-
 Equus caballus phenol + acetate
-
 ?

Synonyms

Synonyms Comment Organism
ChE
-
 Equus caballus

pH Range

pH Minimum pH Maximum Comment Organism
5 7.5 a decrease in pH from 7.5 to 5.0 is accompanied by a 20fold drop in the rate of enzymatic hydrolysis of acetylcholine and a 5fold decrease in the case of phenylacetate. In the case of indophenyl acetate and 2,6-dichlorophenolindophenyl acetate, only a 2.5fold decrease is detected Equus caballus