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Literature summary for 3.1.1.8 extracted from

  • Pan, L.; Tan, J.H.; Hou, J.Q.; Huang, S.L.; Gu, L.Q.; Huang, Z.S.
    Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 3790-3793.
    View publication on PubMed
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
(3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
 Equus caballus
(3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
 Equus caballus
(3E)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
 Equus caballus
(3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
 Equus caballus
(3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
 Equus caballus
2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
 Equus caballus
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
 Equus caballus
3-(4-propoxybenzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
 Equus caballus
3-(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
 Equus caballus
3-(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
 Equus caballus
3-[4-[3-(diethylamino)propoxy]benzyl]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
 Equus caballus
additional information selectivity and inhibitory potency of isaindigotone derivatives for inhibition of BuChE Equus caballus
tacrine
-
 Equus caballus

Organism

Organism UniProt Comment Textmining
Equus caballus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Equus caballus
-

Synonyms

Synonyms Comment Organism
BuChE
-
 Equus caballus
butyrylcholinesterase
-
 Equus caballus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00001
-
-
 Equus caballus tacrine
0.0017
-
-
 Equus caballus (3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
0.003
-
-
 Equus caballus (3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
0.0057
-
-
 Equus caballus 3-(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
0.0071
-
-
 Equus caballus (3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
0.0083
-
-
 Equus caballus 3-(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
0.0127
-
-
 Equus caballus (3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
0.02
-
 above Equus caballus 3-(4-propoxybenzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
0.02
-
 above Equus caballus 3-[4-[3-(diethylamino)propoxy]benzyl]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one