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Literature summary for 3.1.1.8 extracted from

  • Luo, W.; Yu, Q.s.; Zhan, M.; Parrish, D.; Deschamps, J.R.; Kulkarni, S.S.; Holloway, H.W.; Alley, G.M.; Lahiri, D.K.; Brossi, A.; Greig, N.H.
    Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine (2005), J. Med. Chem., 48, 986-994.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (2-methylphenyl)carbamate 50% inhibition at 1950 nM Homo sapiens
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate 50% inhibition at 50 nM Homo sapiens
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl ethylcarbamate 50% inhibition at 4 nM Homo sapiens
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl methylcarbamate 50% inhibition at 16 nM Homo sapiens
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (2-methylphenyl)carbamate 50% inhibition at 1560 nM Homo sapiens
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate 50% inhibition at 17 nM Homo sapiens
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl ethylcarbamate 50% inhibition at 2 nM Homo sapiens
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl methylcarbamate 50% inhibition at 4 nM Homo sapiens
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (2-methylphenyl)carbamate 50% inhibition above 0.030 mM Homo sapiens
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (4-isopropylphenyl)carbamate 50% inhibition at 22 nM Homo sapiens
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl ethylcarbamate 50% inhibition at 24 nM Homo sapiens
2'-ethylphenylgeneserine N-oxide 50% inhibition at 1700 nM Homo sapiens
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (2-methylphenyl)carbamate 50% inhibition above 0.030 mM Homo sapiens
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (4-isopropylphenyl)carbamate 50% inhibition at 27 nM Homo sapiens
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl ethylcarbamate 50% inhibition at 6 nM Homo sapiens
donepezil 50% inhibition at 4150 nM Homo sapiens
eptastigmine 50% inhibition at 5 nM Homo sapiens
galanthamine 50% inhibition at 7300 nM Homo sapiens
huperzine A 50% inhibition above 10000 nM Homo sapiens
additional information comparison of 50% inhibitory concentration for various inhibitors of EC 3.1.1.7 and EC 3.1.1.8 Homo sapiens
phenserine 50% inhibition at 1560 nM Homo sapiens
rivastigmine 50% inhibition at 37 nM Homo sapiens
tacrine 50% inhibition at 47 nM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
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 Homo sapiens
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