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Literature summary for 3.1.1.8 extracted from

  • Sun, H.; El Yazal, J.; Lockridge, O.; Schopfer, L.M.; Brimijoin, S.; Pang, Y.P.
    Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication (2001), J. Biol. Chem., 276, 9330-9336.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.065
-
 (-)-cocaine pH 7.4, 37°C Homo sapiens
107
-
 (+)-cocaine pH 7.4, 25°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-cocaine + H2O
-
 Homo sapiens ?
-
 ?
(-)-cocaine + H2O is hydrolyzed less well than (+)-cocaine Homo sapiens ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0085
-
 (+)-cocaine pH 7.4, 25°C Homo sapiens
0.009
-
 (-)-cocaine pH 7.4, 37°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 (+)-cocaine Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5.5 8.5 no pH dependence of kcat for (-)-cocaine, kcat for (+)-cocaine increases up to pH 7 and decreases above pH 7, Km of both stereoisomers decreases up to pH 8 Homo sapiens