Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | hormone-sensitive lipase is knocked down by RNA interference or selectively inhibited | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q05469 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | women with polycystic ovary syndrome or obesity have significantly decreased expression of hormone-sensitive lipase. Knock down of hormone-sensitive lipase by RNAi reduces basal and catecholamine-induced lipolysis. Treatment of mesenchymal stem cells with a selective inhibitor of hormone-sensitive lipase during and/or after differentiation in adipocytes reduces basal lipolysis by 50% | Homo sapiens | - |