Literature summary for 3.1.1.5 extracted from

Ng, C.K.; Obando, D.; Widmer, F.; Wright, L.C.; Sorrell, T.C.; Jolliffe, K.A.
Correlation of antifungal activity with fungal phospholipase inhibition using a series of bisquaternary ammonium salts (2006), J. Med. Chem., 49, 811-816.

Search for more literature for 3.1.1.5

Application

Application	Comment	Organism
medicine	cryptococcal phospholipase B1 is a virulence factor	Cryptococcus neoformans

Inhibitors

Inhibitors	Comment	Organism	Structure
1,12-bis(tributylammonium)dodecane	-	Cryptococcus neoformans
1,12-bis(trihexylammonium)dodecane	-	Cryptococcus neoformans
1,12-bis(triisopentylammonium)dodecane	-	Cryptococcus neoformans
1,12-bis(tripentylammonium)dodecane	-	Cryptococcus neoformans
1,12-bis(tripropylammonium)dodecane	-	Cryptococcus neoformans

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	-	Cryptococcus neoformans	-	-

Organism

Organism	UniProt	Comment	Textmining
Cryptococcus neoformans	-	-	-

Synonyms

Synonyms	Comment	Organism
PLB1	-	Cryptococcus neoformans

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0035	-	-	Cryptococcus neoformans	1,12-bis(tripentylammonium)dodecane
0.007	-	-	Cryptococcus neoformans	1,12-bis(tripropylammonium)dodecane
0.0075	-	-	Cryptococcus neoformans	1,12-bis(triisopentylammonium)dodecane
0.0075	-	-	Cryptococcus neoformans	1,12-bis(trihexylammonium)dodecane
0.01	-	-	Cryptococcus neoformans	1,12-bis(tributylammonium)dodecane

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Release 2023.1 (January 2023)