Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glycerol | 50% increase of lysophospholipase activity in the presence of 30% glycerol | Pseudomonas aeruginosa |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Pseudomonas aeruginosa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arachidonyl trifluoromethyl ketone | 0.025 mM, approx. 50% inhibition | Pseudomonas aeruginosa | |
bromoenol lactone | 0.025 mM, approx. 30% inhibition | Pseudomonas aeruginosa | |
trifluoromethyl ketone | 0.025 mM, approx. 40% inhibition | Pseudomonas aeruginosa | |
Triton X-100 | - |
Pseudomonas aeruginosa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | Ca2+ independent phospholipase A2 activity | Pseudomonas aeruginosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-lysophosphatidylcholine + H2O | Pseudomonas aeruginosa | - |
glycerophosphocholine + a carboxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant ExoU | Pseudomonas aeruginosa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-palmitylphosphatidylcholine + H2O | low activity after activating of ExoU with an unknown eukaryotic cell factor | Pseudomonas aeruginosa | 1-palmityl-lysophosphatidylcholine + palmitic acid | - |
? | |
1-palmitoyl-lysophosphatidylcholine + H2O | - |
Pseudomonas aeruginosa | glycerophosphocholine + palmitic acid | - |
? | |
2-lysophosphatidylcholine + H2O | - |
Pseudomonas aeruginosa | glycerophosphocholine + a carboxylate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ExoU | - |
Pseudomonas aeruginosa |
lysoPLA | - |
Pseudomonas aeruginosa |