Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D49K | suramin affinity is increased, inhibitory effect of suramin in relation to wild-type protein is enhanced | Homo sapiens |
DELTAK57/R58 | suramin affinity is significantly increased | Homo sapiens |
H48Q | inhibitory effect of suramin in relation to wild-type protein is enhanced | Homo sapiens |
K116A | suramin affinity is increased, inhibitory effect of suramin in relation to wild-type protein is enhanced | Homo sapiens |
K123A | suramin affinity is significantly reduced, inhibitory effect of suramin in relation to wild-type protein is reduced | Homo sapiens |
K15A | suramin affinity is significantly reduced, inhibitory effect of suramin in relation to wild-type protein is reduced | Homo sapiens |
additional information | The changes in suramin binding affinity of cationic residue mutants of is strongly correlated with alterations in the inhibition of membrane damaging activity of the protein | Homo sapiens |
R54A | suramin affinity is significantly reduced, inhibitory effect of suramin in relation to wild-type protein is reduced | Homo sapiens |
R58A | inhibitory effect of suramin in relation to wild-type protein is reduced | Homo sapiens |
R7A | inhibitory effect of suramin in relation to wild-type protein is reduced | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
suramin | the C-terminal region of the enzyme is crucial to the stabilization of the complex with suramin and consequently is a major structural determinant of the inhibitory action of suramin | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14555 | - |
- |