Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.4 extracted from

  • Burke, J.; Dennis, E.
    Phospholipase A2 structure/function, mechanism, and signaling (2009), J. Lipid Res., 50 Suppl, S237-S242.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information activity of the GVIA PLA2 may be regulated through many different mechanisms, including ATP binding, caspase cleavage, calmodulin, and possible ankyrin repeat mediated protein aggregation Homo sapiens

Application

Application Comment Organism
drug development with the classification of GVIIA PLA2 as a positive risk factor in coronary heart disease, it has become a very attractive drug target. Recent clinical trials with GVIIA PLA2 inhibitor have shown a decrease in the complex atherosclerotic lesions that lead to unstable lesions, as well as other cardiovascular disease markers Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
GIVA PLA2 and GVIIA PLA2 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bromoenollactone is not specific for GVIA PLA2 and actually functions through activation of the inhibitor by GVIA PLA2 followed by nonspecific covalent modification of cysteine residues in all proximally located enzymes Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol GIVA PLA2 Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information GIVA PLA2 does not require Ca2+ for catalytic activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Apis mellifera
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Naja naja
-
-
-

Purification (Commentary)

Purification (Comment) Organism
GVIA PLA2 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet GIVA PLA2 Homo sapiens
-
macrophage GIVA PLA2 and GVIA PLA2 Homo sapiens
-
additional information synovial fluid, GIIA PLA2 Homo sapiens
-
plasma GVIIA PLA2 Homo sapiens
-
venom group IA PLA2 Naja naja
-
venom group III PLA2 Apis mellifera
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information active splice forms of the enzyme GIVA-1 PLA2 and GIVA-2 PLA2 are composed of 7-8 ankyrin repeats, a linker region and a catalytic domain, uses a serine in the active site to catalyze the cleavage of the sn-2 ester bond Homo sapiens ?
-
?
additional information group IA enzyme appears to bind lipid substrate in the active site through the hydrophobic residues lining the active site channel, and binds neutral membrane substrate through interactions with a group of hydrophobic residues on the lipid binding surface of the molecule Naja naja ?
-
?
additional information similar activity to phospholipids with different fatty acids in the sn-2 position, but with different preferences for the charge on the lipid surface Apis mellifera ?
-
?

Synonyms

Synonyms Comment Organism
Ca2+ independent PLA2 group VIA PLA2 Homo sapiens
cytosolic calcium-dependent PLA2 GIVA PLA2 Homo sapiens
GIIA PLA2
-
Homo sapiens
GIVA PLA2
-
Mus musculus
GIVA PLA2 cytosolic calcium-dependent PLA2 Homo sapiens
group IA PLA2
-
Naja naja
group IIA PLA2
-
Homo sapiens
group III PLA2
-
Apis mellifera
group IVA PLA2 cytosolic calcium-dependent PLA2 Homo sapiens
Group VIA PLA2
-
Homo sapiens
GVIA PLA2
-
Mus musculus
GVIA PLA2
-
Homo sapiens
GVIIA PLA2 PAF acetyl hydrolase/oxidized lipid LpPLA2 Homo sapiens
PAF acetyl hydrolase/oxidized lipid LpPLA2
-
Homo sapiens
phospholipase A2
-
Mus musculus
phospholipase A2
-
Homo sapiens
phospholipase A2
-
Apis mellifera
phospholipase A2
-
Naja naja
platelet activating factor acetyl hydrolase/oxidized lipid LpPLA2 GVIIA PLA2 Homo sapiens

General Information

General Information Comment Organism
malfunction absence of the GIVA PLA2 gene significantly reduces the effects of many inflammatory disease Mus musculus
malfunction patient with defects in GIVA PLA2 shows decreases in PLA2 activity, eicosanoid biosynthesis, and the generation of many small intestinal ulcers Homo sapiens
physiological function GIIA PLA2 is a potent antimicrobial agent. Role of the GVIA PLA2 in different signaling pathways. GVIIA PLA2 has anti-inflammatory activity in vivo, is a positive risk factor in coronary heart disease Homo sapiens
physiological function GVIA PLA2 plays an important role in bone formation, apoptosis, insulin secretion, and sperm development. GVIA PLA2 in combination with the GIVA PLA2 play an important role in Wallerian degeneration and axon regeneration in nerve injury. GIVA PLA2 is generally considered to be a central enzyme mediating generation of eicosanoids and hence many inflammatory processes Mus musculus