Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | IL-8/CXCL8-induces gIVaPLA2 phosphorylation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arachidonyl trifluoromethylketone | causes inhibition to baseline level of gIVaPLA2 activity caused by IL-8/CXCL8 | Homo sapiens | |
additional information | inhibition of gIVaPLA2 blocks the deformability and subsequent migration of polymophonuclear leukocytes caused by IL-8/CXCL8 | Homo sapiens | |
pyrrophenone | potent gIVaPLA2 inhibitor, attenuates gIVaPLA2 activity in concentration-dependent manner | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | is located mainly in cytoplasm of unstimulated polymorphonuclear leukocytes | Homo sapiens | 5829 | - |
nuclear membrane | time-related phosphorylation and translocation of cytosolic gIVaPLA2 to the nucleus for polymorphonuclear leukocytes stimulated with IL-8/CXCL8 in concentration sufficient to cause upstream phosphorylation of MAPKs (ERK-1/2 and p38) and Akt/PKB | Homo sapiens | 31965 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
polymorphonuclear leukocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-palmitoyl-2-arachidonyl-phosphatidylcholine + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytosolic gIVaPLA2 | - |
Homo sapiens |
cytosolic group IVa phospholipase A2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | activation of gIVaPLA2 is an essential step in polymophonuclear leukocyte migration in vitro. Change in polymorphonuclear leukocyte cell shape and migration correspond to increased activity of cytosolic gIVaPLA2 and translocation of gIVaPLA2 to the nuclear membrane. F-actin polymerization, another essential step for cell migration, is not regulated by gIVaPLA2 | Homo sapiens |