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Literature summary for 3.1.1.4 extracted from
- Genistein, a potent inhibitor of secretory phospholipase A2: a new insight in down regulation of inflammation (2010), Inflammopharmacology, 18, 25-31.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| genistein | inhibits sPLA(2) enzymes of inflammatory exudates in a concentration dependent manner. Increasing the Ca2+ concentration from 2.5 to 15 mM and substrate concentration up to 0.000120 mM does not alter the level of inhibition | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | synovial fluid | Homo sapiens | - |
| pleural fluid | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | 14C-oleate radio-labelled Escherichia coli membrane used as substrate | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| secretory phospholipase A2 | - |
Homo sapiens |
| sPLA(2) | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | sPLA(2) induces mouse paw oedema | Homo sapiens |
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