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Literature summary for 3.1.1.4 extracted from

  • Hess, M.; Schulze Elfringhoff, A.; Lehr, M.
    Design and synthesis of 3-pyrrol-3-yl-3H-isobenzofuran-1-ones as inhibitors of human cytosolic phospholipase A2alpha (2008), J. Enzyme Inhib. Med. Chem., 23, 946-957.
    View publication on PubMed
Search for more literature for 3.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
3-(1-benzyl-2,5-dimethylpyrrol-3-yl)-3-(4-fluorophenyl)-3H-isobenzofuran-1-one 18% inhibition at 0.033 mM Homo sapiens
3-(2,5-dimethyl-1-phenylpyrrol-3-yl)-3-(4-fluorophenyl)-3H-isobenzofuran-1-one 40% inhibition at 0.033 mM Homo sapiens
3-(2,5-dimethylpyrrol-3-yl)-3-(4-fluorophenyl)-3H-isobenzofuran-1-one 35% inhibition at 0.033 mM Homo sapiens
3-(4-fluorophenyl)-3-(1,2,5-trimethylpyrrol-3-yl)-3H-isobenzofuran-1-one 36% inhibition at 0.033 mM Homo sapiens
3-(4-fluorophenyl)-3-[1-(3-hydroxyphenyl)-2,5-dimethylpyrrol-3-yl]-3H-isobenzofuran-1-one 30% inhibition at 0.033 mM Homo sapiens
3-(4-fluorophenyl)-3-[1-(4-hydroxyphenyl)-2,5-dimethylpyrrol-3-yl]-3H-isobenzofuran-1-one 60% inhibition at 0.033 mM Homo sapiens
3-pyrrol-3-yl-3H-isobenzofuran-1-one synthesis and inhibitory potency of derivatives, overview Homo sapiens
3-[1-(3,4-dihydroxyphenyl)-2,5-dimethylpyrrol-3-yl]-3-(4-fluorophenyl)-3H-isobenzofuran-1-one 20% inhibition at 0.033 mM Homo sapiens
3-[1-(4-aminophenyl)-2,5-dimethylpyrrol-3-yl]-3-(4-fluorophenyl)-3H-isobenzofuran-1-one 55% inhibition at 0.033 mM Homo sapiens
3-[2,5-dimethyl-1-(4-methylaminophenyl)pyrrol-3-yl]-3-(4-fluorophenyl)-3H-isobenzofuran-1-one 36% inhibition at 0.033 mM Homo sapiens
4-(2,4-dioxothiazolidin-5-ylidenemethyl)-N-(4-[1-(4-fluorophenyl)-3-one-1H-isobenzofuran-1-yl]-2,5-dimethyl-1-phenylpyrrol-3-ylmethyl)benzamide
-
 Homo sapiens
4-(3-[1-(4-fluorophenyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl]-2,5-dimethylpyrrol-1-yl)benzamide 42% inhibition at 0.033 mM Homo sapiens
4-(3-[1-(4-fluorophenyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl]-2,5-dimethylpyrrol-1-yl)benzoic acid 51% inhibition at 0.033 mM Homo sapiens
5-(4-[3-(1-[4-fluorophenyl]-3-oxo-1,3-dihydroisobenzofuran-1-yl)-2,5-dimethyl-pyrrol-1-yl]benzylidene)thiazolidine-2,4-dione 76% inhibition at 0.033 mM Homo sapiens
arachidonyltrifluoromethyl ketone
-
 Homo sapiens
additional information structure-activity relationship, overview Homo sapiens
N-(4-[3-(1-(4-fluorophenyl)3-oxo-1,3-dihydroisobenzofuran-1-yl)-2,5-dimethylpyrrol-1-yl]phenyl)acetamide 35% inhibition at 0.033 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
cPLA2alpha
-
 Homo sapiens
cytosolic phospholipase A2alpha
-
 Homo sapiens