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Literature summary for 3.1.1.4 extracted from

  • Rigoni, M.; Paoli, M.; Milanesi, E.; Caccin, P.; Rasola, A.; Bernardi, P.; Montecucco, C.
    Snake phospholipase A2 neurotoxins enter neurons, bind specifically to mitochondria, and open their transition pores (2008), J. Biol. Chem., 283, 34013-34020.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.4

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Vipera ammodytes
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-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Vipera ammodytes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Vipera ammodytes the snake phospholipase A2 neurotoxins enter nerve terminals, bind specifically to mitochondria, and open their transition pores, overview. The action of SPANs is very specific for the presynaptic nerve terminals in vivo ?
-
 ?

Organism

Organism UniProt Comment Textmining
Vipera ammodytes
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information intracellular localization of SPANs in different primary neuronal cultures from rats and mice after application, fluorescent neurotoxin is not homogeneously distributed in the cytosol but rather localized to elongated, spaghetti-like structures that are clearly reminiscent of mitochondria, overview Vipera ammodytes
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venom
-
 Vipera ammodytes
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the snake phospholipase A2 neurotoxins enter nerve terminals, bind specifically to mitochondria, and open their transition pores, overview. The action of SPANs is very specific for the presynaptic nerve terminals in vivo Vipera ammodytes ?
-
 ?

Synonyms

Synonyms Comment Organism
ammodytoxin A
-
 Vipera ammodytes
phospholipase A2 neurotoxin
-
 Vipera ammodytes
PLA2 neurotoxin
-
 Vipera ammodytes
snake presynoptic phospholipase A2 neurotoxin
-
 Vipera ammodytes
SPAN
-
 Vipera ammodytes