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Literature summary for 3.1.1.4 extracted from

  • De Luca, D.; Minucci, A.; Zecca, E.; Piastra, M.; Pietrini, D.; Carnielli, V.P.; Zuppi, C.; Tridente, A.; Conti, G.; Capoluongo, E.D.
    Bile acids cause secretory phospholipase A2 activity enhancement, revertible by exogenous surfactant administration (2009), Intensive Care Med., 35, 321-326.
    View publication on PubMed
Search for more literature for 3.1.1.4

Activating Compound

Activating Compound Comment Organism Structure
bile acid bile acids cause sPLA2 activity enhancement, revertible by exogenous surfactant administration, overview. Bile acids are likely to contribute to lung injury, causing surfactant inactivation through the increased sPLA2 activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diheptanoyl phosphatidylcholine + H2O Homo sapiens
-
 1-heptanoyl-sn-glycerophosphocholine + heptanoic acid
-
 ?
additional information Homo sapiens bile acids are likely to contribute to lung injury, causing surfactant inactivation through the increased sPLA2 activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung broncho-alveolar lavage Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-diheptanoyl phosphatidylcholine + H2O
-
 Homo sapiens 1-heptanoyl-sn-glycerophosphocholine + heptanoic acid
-
 ?
diheptanoyl phosphatidylcholine + H2O
-
 Homo sapiens 1-heptanoyl-sn-glycerophosphocholine + heptanoic acid
-
 ?
additional information bile acids are likely to contribute to lung injury, causing surfactant inactivation through the increased sPLA2 activity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
secretory phospholipase A2
-
 Homo sapiens
sPLA2
-
 Homo sapiens