Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3,5-trihydroxybenzene | potent inhibition of enzymatic activity and endemic activity of PLA2, binding structure, overview | Crotalus adamanteus | |
1,3-dihydroxy benzene | potent inhibition of enzymatic activity and endemic activity of PLA2, binding structure, overview | Crotalus adamanteus | |
2,4,6-trihydroxy acetophenone | potent inhibition of enzymatic activity and endemic activity of PLA2, binding structure, overview | Crotalus adamanteus | |
2,4-dihydroxy acetophenone | binding structure, overview | Crotalus adamanteus | |
2,6-dihydroxy acetophenone | binding structure, overview | Crotalus adamanteus | |
additional information | molecular modeling of the inhibition mechanism of polyhydroxylated phenols | Crotalus adamanteus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Crotalus adamanteus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crotalus adamanteus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme by gel filtration and C18 reverse phase HPLC | Crotalus adamanteus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Crotalus adamanteus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphoglycerol + H2O | micellar substrate | Crotalus adamanteus | ? | - |
? | |
additional information | the enzyme causes endema when applicated to the right footpad of male Swiss mice | Crotalus adamanteus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Crotalus adamanteus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Crotalus adamanteus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000872 | - |
1,3-dihydroxy benzene | pH 8.0, 37°C | Crotalus adamanteus | |
0.00000874 | - |
2,4,6-trihydroxy acetophenone | pH 8.0, 37°C | Crotalus adamanteus | |
0.00000877 | - |
1,3,5-trihydroxybenzene | pH 8.0, 37°C | Crotalus adamanteus | |
0.00003 | - |
2,6-dihydroxy acetophenone | pH 8.0, 37°C | Crotalus adamanteus | |
0.000032 | - |
2,4-dihydroxy acetophenone | pH 8.0, 37°C | Crotalus adamanteus |