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Literature summary for 3.1.1.4 extracted from

  • Bate, C.; Tayebi, M.; Williams, A.
    Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2 activation (2008), BMC Biol., 6, 8.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.4

Activating Compound

Activating Compound Comment Organism Structure
additional information cPLA2 is activated by phosphorylation involving the cellular prion protein, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus prion infection greatly increased both the phosphorylation of cPLA2 and prostaglandin E2 production, the alternatively folded prion protein PrPSc causes a dose-dependent increase in the free cholesterol concentration of cortical neurons, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein prion infection greatly increased the phosphorylation of cPLA2 leading to increased activation of the PLA2 pathway Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus
-
 Mus musculus
-
additional information the enzyme co-precipitates with the alternatively folded cellular prion protein isoform PrPSc Mus musculus
-
neuron primary cortical neurons Mus musculus
-
neuronal cell
-
 Mus musculus
-
ScGT1 cell a hypothalamic neuronal cell line Mus musculus
-
ScN2a cell a hypothalamic neuronal cell line Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information prion infection greatly increased both the phosphorylation of cPLA2 and prostaglandin E2 production, the alternatively folded prion protein PrPSc causes a dose-dependent increase in the free cholesterol concentration of cortical neurons, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
cPLA2
-
 Mus musculus
cytoplasmic phospholipase A2
-
 Mus musculus