Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the MAPK-dependent enzyme is induced by pigment epithelium-derived factor and activated by phosphorylation at Ser505 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dantrolene | - |
Homo sapiens | |
methyl arachidonyl fluorophosphonate | - |
Homo sapiens | |
nifedipine | - |
Homo sapiens | |
SB-203580 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | cPLA2-alpha is phosphorylated and translocated to the nucleus | Homo sapiens | 5829 | - |
nucleus | cPLA2-alpha is phosphorylated and translocated to the nucleus | Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | cPLA2-alpha is phosphorylated at Ser505, MAPK-dependent, and translocated to the nucleus | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
human umbilical vein endothelial cell | i.e. HUVEC | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | - |
Homo sapiens | 1-acylglycerophosphocholine + a carboxylate | - |
? | |
pigment epithelium-derived 6 + H2O | i.e. PED6, a synthetic substrate | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cPLA2-alpha | - |
Homo sapiens |
cytosolic phospholipase A2-alpha | - |
Homo sapiens |