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Literature summary for 3.1.1.4 extracted from

  • Lee, V.T.; Pukatzki, S.; Sato, H.; Kikawada, E.; Kazimirova, A.A.; Huang, J.; Li, X.; Arm, J.P.; Frank, D.W.; Lory, S.
    Pseudolipasin A is a specific inhibitor for phospholipase A2 activity of Pseudomonas aeruginosa cytotoxin ExoU (2007), Infect. Immun., 75, 1089-1098.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
(9Z)-9-(hydroxyimino)-9H-fluorene-4-carboxamide inhibition of phospholipase A2 activity of cytotoxin ExoU Pseudomonas aeruginosa
1-(9H-fluoren-4-ylcarbonyl)piperidine inhibition of phospholipase A2 activity of cytotoxin ExoU Pseudomonas aeruginosa
9-oxo-9H-fluorene-3-carboxamide inhibition of phospholipase A2 activity of cytotoxin ExoU Pseudomonas aeruginosa
9H-carbazole-4-carboxamide inhibition of phospholipase A2 activity of cytotoxin ExoU Pseudomonas aeruginosa
9H-fluoren-4-ol inhibition of phospholipase A2 activity of cytotoxin ExoU Pseudomonas aeruginosa
9H-fluorene-4-carboxamide inhibition of phospholipase A2 activity of cytotoxin ExoU Pseudomonas aeruginosa
biphenylene-1-carbonyl chloride inhibition of phospholipase A2 activity of cytotoxin ExoU Pseudomonas aeruginosa
methyl 9H-fluorene-4-carboxylate inhibition of phospholipase A2 activity of cytotoxin ExoU Pseudomonas aeruginosa
additional information high-throughput inhibitor screening, overview Pseudomonas aeruginosa
N,N-dimethyl-9H-fluorene-4-carboxamide inhibition of phospholipase A2 activity of cytotoxin ExoU Pseudomonas aeruginosa
N-9H-fluoren-2-ylformamide inhibition of phospholipase A2 activity of cytotoxin ExoU Pseudomonas aeruginosa
N-9H-fluoren-4-ylacetamide inhibition of phospholipase A2 activity of cytotoxin ExoU Pseudomonas aeruginosa
N-phenyl-9H-fluorene-4-carboxamide inhibition of phospholipase A2 activity of cytotoxin ExoU Pseudomonas aeruginosa
pseudolipasin A a specific inhibitor for phospholipase A2 activity of cytotoxin ExoU Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas aeruginosa exoenzyme U, i.e. ExoU, a potent cytotoxin, is delivered via the type III secretion pathway directly into contacting host cells, once inside the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A2 activity, overview ?
-
 ?
additional information Pseudomonas aeruginosa PAK-VL1 exoenzyme U, i.e. ExoU, a potent cytotoxin, is delivered via the type III secretion pathway directly into contacting host cells, once inside the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A2 activity, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-
Pseudomonas aeruginosa PAK-VL1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information exoenzyme U, i.e. ExoU, a potent cytotoxin, is delivered via the type III secretion pathway directly into contacting host cells, once inside the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A2 activity, overview Pseudomonas aeruginosa ?
-
 ?
additional information exoenzyme U, i.e. ExoU, a potent cytotoxin, is delivered via the type III secretion pathway directly into contacting host cells, once inside the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A2 activity, overview Pseudomonas aeruginosa PAK-VL1 ?
-
 ?

Synonyms

Synonyms Comment Organism
cytotoxin ExoU
-
 Pseudomonas aeruginosa
exoenzyme U
-
 Pseudomonas aeruginosa
ExoU-specific PLA2
-
 Pseudomonas aeruginosa
PLA2
-
 Pseudomonas aeruginosa