Cloned (Comment) | Organism |
---|---|
expression in HEK293 cells | Homo sapiens |
expression of isozyme sPLA2IB2 in HEK293 cells | Homo sapiens |
expression of isozymes in HEK293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,2'-biphenyl-3,4'-diylbis(4H-chromen-4-one) | slight inhibition | Homo sapiens | |
2,2'-biphenyl-4,4'-diylbis(4H-chromen-4-one) | slight inhibition | Homo sapiens | |
2,2'-diphenyl-4H,4'H-6,6'-bichromene-4,4'-dione | slight inhibition | Homo sapiens | |
3-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | slight inhibition | Homo sapiens | |
6-[3-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | slight inhibition | Homo sapiens | |
6-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | slight inhibition | Homo sapiens | |
amentoflavone | slight inhibition | Homo sapiens | |
ochnaflavone | slight inhibition | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isozyme cPLA2 | Homo sapiens | 5829 | - |
extracellular | isozyme sPLA2IB2 | Homo sapiens | - |
- |
extracellular | isozymes sPLA2-IIA, sPLA2-V, and sPLA2-X | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme sPLA2IB2 | - |
Homo sapiens | - |
isozymes sPLA2-IIA, sPLA2-V, and sPLA2-X | - |
Homo sapiens | P47712 | cPLA2; isozyme cPLA2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-acyl-2-arachidonoyl-sn-glycerol phosphoethanolamine + H2O | radiolabeled substrate | Homo sapiens | 1-acyl-sn-glycerol phosphoethanolamine + arachidonate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cPLA2 | - |
Homo sapiens |
phospholipase A2s | - |
Homo sapiens |
PLA2s | - |
Homo sapiens |
sPLA2-IIA | - |
Homo sapiens |
sPLA2-V | - |
Homo sapiens |
sPLA2-X | - |
Homo sapiens |
sPLA2IB2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.003 | - |
pH 9.0, 37°C, isozyme sPLA2-IIA | Homo sapiens | ochnaflavone | |
0.0035 | - |
pH 9.0, 37°C, isozyme sPLA2-IIA | Homo sapiens | 3-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.006 | - |
pH 9.0, 37°C, isozyme cPLA2 | Homo sapiens | ochnaflavone | |
0.0065 | - |
pH 9.0, 37°C, isozyme sPLA2-V | Homo sapiens | 6-[3-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.0087 | - |
pH 9.0, 37°C, isozyme sPLA2-V | Homo sapiens | ochnaflavone | |
0.009 | - |
pH 9.0, 37°C, isozyme cPLA2 | Homo sapiens | 6-[3-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.011 | - |
pH 9.0, 37°C, isozyme sPLA2-V | Homo sapiens | 2,2'-biphenyl-4,4'-diylbis(4H-chromen-4-one) | |
0.012 | - |
pH 9.0, 37°C, isozyme cPLA2 | Homo sapiens | 2,2'-biphenyl-4,4'-diylbis(4H-chromen-4-one) | |
0.013 | - |
pH 9.0, 37°C, isozyme sPLA2-V | Homo sapiens | 2,2'-biphenyl-3,4'-diylbis(4H-chromen-4-one) | |
0.016 | - |
pH 9.0, 37°C, isozyme sPLA2-IIA | Homo sapiens | amentoflavone | |
0.017 | - |
pH 9.0, 37°C, isozyme cPLA2 | Homo sapiens | 2,2'-biphenyl-3,4'-diylbis(4H-chromen-4-one) | |
0.018 | - |
pH 9.0, 37°C, isozyme sPLA2-V | Homo sapiens | 3-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.02 | - |
pH 9.0, 37°C, isozyme sPLA2-IIA | Homo sapiens | 2,2'-biphenyl-3,4'-diylbis(4H-chromen-4-one) | |
0.023 | - |
pH 9.0, 37°C, isozyme sPLA2-IIA | Homo sapiens | 6-[3-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.024 | - |
pH 9.0, 37°C, isozyme sPLA2-IIA | Homo sapiens | 2,2'-diphenyl-4H,4'H-6,6'-bichromene-4,4'-dione | |
0.024 | - |
pH 9.0, 37°C, isozyme sPLA2-V | Homo sapiens | amentoflavone | |
0.028 | - |
pH 9.0, 37°C, isozyme sPLA2-X | Homo sapiens | 6-[3-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.039 | - |
pH 9.0, 37°C, isozyme cPLA2 | Homo sapiens | amentoflavone | |
0.042 | - |
pH 9.0, 37°C, isozyme sPLA2-V | Homo sapiens | 2,2'-diphenyl-4H,4'H-6,6'-bichromene-4,4'-dione | |
0.048 | - |
pH 9.0, 37°C, isozyme cPLA2 | Homo sapiens | 6-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.05 | - |
pH 9.0, 37°C, isozyme sPLA2-V | Homo sapiens | 6-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.064 | - |
pH 9.0, 37°C, isozyme sPLA2-IIA | Homo sapiens | 2,2'-biphenyl-4,4'-diylbis(4H-chromen-4-one) | |
0.069 | - |
pH 9.0, 37°C, isozyme sPLA2-IIA | Homo sapiens | 6-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.1 | - |
above, pH 9.0, 37°C, isozyme cPLA2 | Homo sapiens | 2,2'-diphenyl-4H,4'H-6,6'-bichromene-4,4'-dione | |
0.1 | - |
above, pH 9.0, 37°C, isozyme cPLA2 | Homo sapiens | 3-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.1 | - |
above, pH 9.0, 37°C, isozyme sPLA2-V | Homo sapiens | 2,2'-biphenyl-3,4'-diylbis(4H-chromen-4-one) | |
0.1 | - |
above, pH 9.0, 37°C, isozyme sPLA2-X | Homo sapiens | 2,2'-biphenyl-4,4'-diylbis(4H-chromen-4-one) | |
0.1 | - |
above, pH 9.0, 37°C, isozyme sPLA2-X | Homo sapiens | 6-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.1 | - |
above, pH 9.0, 37°C, isozyme sPLA2-X | Homo sapiens | 2,2'-diphenyl-4H,4'H-6,6'-bichromene-4,4'-dione | |
0.1 | - |
above, pH 9.0, 37°C, isozyme sPLA2-X | Homo sapiens | 3-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.1 | - |
above, pH 9.0, 37°C, isozyme sPLA2IB2 | Homo sapiens | amentoflavone | |
0.1 | - |
above, pH 9.0, 37°C, isozyme sPLA2IB2 | Homo sapiens | ochnaflavone | |
0.1 | - |
above, pH 9.0, 37°C, isozyme sPLA2IB2 | Homo sapiens | 2,2'-biphenyl-4,4'-diylbis(4H-chromen-4-one) | |
0.1 | - |
above, pH 9.0, 37°C, isozyme sPLA2IB2 | Homo sapiens | 2,2'-biphenyl-3,4'-diylbis(4H-chromen-4-one) | |
0.1 | - |
above, pH 9.0, 37°C, isozyme sPLA2IB2 | Homo sapiens | 6-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.1 | - |
above, pH 9.0, 37°C, isozyme sPLA2IB2 | Homo sapiens | 6-[3-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.1 | - |
above, pH 9.0, 37°C, isozyme sPLA2IB2 | Homo sapiens | 2,2'-diphenyl-4H,4'H-6,6'-bichromene-4,4'-dione | |
0.1 | - |
above, pH 9.0, 37°C, isozyme sPLA2IB2 | Homo sapiens | 3-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one | |
0.1 | - |
pH 9.0, 37°C, isozyme sPLA2-X | Homo sapiens | amentoflavone | |
0.1 | - |
pH 9.0, 37°C, isozyme sPLA2-X | Homo sapiens | ochnaflavone |