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Literature summary for 3.1.1.4 extracted from

  • Moon, T.C.; Quan, Z.; Kim, J.; Kim, H.P.; Kudo, I.; Murakami, M.; Park, H.; Chang, H.W.
    Inhibitory effect of synthetic C-C biflavones on various phospholipase A2s activity (2007), Bioorg. Med. Chem., 15, 7138-7143.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK293 cells Homo sapiens
expression of isozyme sPLA2IB2 in HEK293 cells Homo sapiens
expression of isozymes in HEK293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,2'-biphenyl-3,4'-diylbis(4H-chromen-4-one) slight inhibition Homo sapiens
2,2'-biphenyl-4,4'-diylbis(4H-chromen-4-one) slight inhibition Homo sapiens
2,2'-diphenyl-4H,4'H-6,6'-bichromene-4,4'-dione slight inhibition Homo sapiens
3-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one slight inhibition Homo sapiens
6-[3-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one slight inhibition Homo sapiens
6-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one slight inhibition Homo sapiens
amentoflavone slight inhibition Homo sapiens
ochnaflavone slight inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isozyme cPLA2 Homo sapiens 5829
-
extracellular isozyme sPLA2IB2 Homo sapiens
-
-
extracellular isozymes sPLA2-IIA, sPLA2-V, and sPLA2-X Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozyme sPLA2IB2
-
Homo sapiens
-
isozymes sPLA2-IIA, sPLA2-V, and sPLA2-X
-
Homo sapiens P47712 cPLA2; isozyme cPLA2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-acyl-2-arachidonoyl-sn-glycerol phosphoethanolamine + H2O radiolabeled substrate Homo sapiens 1-acyl-sn-glycerol phosphoethanolamine + arachidonate
-
?

Synonyms

Synonyms Comment Organism
cPLA2
-
Homo sapiens
phospholipase A2s
-
Homo sapiens
PLA2s
-
Homo sapiens
sPLA2-IIA
-
Homo sapiens
sPLA2-V
-
Homo sapiens
sPLA2-X
-
Homo sapiens
sPLA2IB2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.003
-
pH 9.0, 37°C, isozyme sPLA2-IIA Homo sapiens ochnaflavone
0.0035
-
pH 9.0, 37°C, isozyme sPLA2-IIA Homo sapiens 3-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.006
-
pH 9.0, 37°C, isozyme cPLA2 Homo sapiens ochnaflavone
0.0065
-
pH 9.0, 37°C, isozyme sPLA2-V Homo sapiens 6-[3-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.0087
-
pH 9.0, 37°C, isozyme sPLA2-V Homo sapiens ochnaflavone
0.009
-
pH 9.0, 37°C, isozyme cPLA2 Homo sapiens 6-[3-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.011
-
pH 9.0, 37°C, isozyme sPLA2-V Homo sapiens 2,2'-biphenyl-4,4'-diylbis(4H-chromen-4-one)
0.012
-
pH 9.0, 37°C, isozyme cPLA2 Homo sapiens 2,2'-biphenyl-4,4'-diylbis(4H-chromen-4-one)
0.013
-
pH 9.0, 37°C, isozyme sPLA2-V Homo sapiens 2,2'-biphenyl-3,4'-diylbis(4H-chromen-4-one)
0.016
-
pH 9.0, 37°C, isozyme sPLA2-IIA Homo sapiens amentoflavone
0.017
-
pH 9.0, 37°C, isozyme cPLA2 Homo sapiens 2,2'-biphenyl-3,4'-diylbis(4H-chromen-4-one)
0.018
-
pH 9.0, 37°C, isozyme sPLA2-V Homo sapiens 3-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.02
-
pH 9.0, 37°C, isozyme sPLA2-IIA Homo sapiens 2,2'-biphenyl-3,4'-diylbis(4H-chromen-4-one)
0.023
-
pH 9.0, 37°C, isozyme sPLA2-IIA Homo sapiens 6-[3-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.024
-
pH 9.0, 37°C, isozyme sPLA2-IIA Homo sapiens 2,2'-diphenyl-4H,4'H-6,6'-bichromene-4,4'-dione
0.024
-
pH 9.0, 37°C, isozyme sPLA2-V Homo sapiens amentoflavone
0.028
-
pH 9.0, 37°C, isozyme sPLA2-X Homo sapiens 6-[3-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.039
-
pH 9.0, 37°C, isozyme cPLA2 Homo sapiens amentoflavone
0.042
-
pH 9.0, 37°C, isozyme sPLA2-V Homo sapiens 2,2'-diphenyl-4H,4'H-6,6'-bichromene-4,4'-dione
0.048
-
pH 9.0, 37°C, isozyme cPLA2 Homo sapiens 6-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.05
-
pH 9.0, 37°C, isozyme sPLA2-V Homo sapiens 6-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.064
-
pH 9.0, 37°C, isozyme sPLA2-IIA Homo sapiens 2,2'-biphenyl-4,4'-diylbis(4H-chromen-4-one)
0.069
-
pH 9.0, 37°C, isozyme sPLA2-IIA Homo sapiens 6-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.1
-
above, pH 9.0, 37°C, isozyme cPLA2 Homo sapiens 2,2'-diphenyl-4H,4'H-6,6'-bichromene-4,4'-dione
0.1
-
above, pH 9.0, 37°C, isozyme cPLA2 Homo sapiens 3-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.1
-
above, pH 9.0, 37°C, isozyme sPLA2-V Homo sapiens 2,2'-biphenyl-3,4'-diylbis(4H-chromen-4-one)
0.1
-
above, pH 9.0, 37°C, isozyme sPLA2-X Homo sapiens 2,2'-biphenyl-4,4'-diylbis(4H-chromen-4-one)
0.1
-
above, pH 9.0, 37°C, isozyme sPLA2-X Homo sapiens 6-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.1
-
above, pH 9.0, 37°C, isozyme sPLA2-X Homo sapiens 2,2'-diphenyl-4H,4'H-6,6'-bichromene-4,4'-dione
0.1
-
above, pH 9.0, 37°C, isozyme sPLA2-X Homo sapiens 3-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.1
-
above, pH 9.0, 37°C, isozyme sPLA2IB2 Homo sapiens amentoflavone
0.1
-
above, pH 9.0, 37°C, isozyme sPLA2IB2 Homo sapiens ochnaflavone
0.1
-
above, pH 9.0, 37°C, isozyme sPLA2IB2 Homo sapiens 2,2'-biphenyl-4,4'-diylbis(4H-chromen-4-one)
0.1
-
above, pH 9.0, 37°C, isozyme sPLA2IB2 Homo sapiens 2,2'-biphenyl-3,4'-diylbis(4H-chromen-4-one)
0.1
-
above, pH 9.0, 37°C, isozyme sPLA2IB2 Homo sapiens 6-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.1
-
above, pH 9.0, 37°C, isozyme sPLA2IB2 Homo sapiens 6-[3-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.1
-
above, pH 9.0, 37°C, isozyme sPLA2IB2 Homo sapiens 2,2'-diphenyl-4H,4'H-6,6'-bichromene-4,4'-dione
0.1
-
above, pH 9.0, 37°C, isozyme sPLA2IB2 Homo sapiens 3-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
0.1
-
pH 9.0, 37°C, isozyme sPLA2-X Homo sapiens amentoflavone
0.1
-
pH 9.0, 37°C, isozyme sPLA2-X Homo sapiens ochnaflavone