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Literature summary for 3.1.1.4 extracted from

  • Hurley, B.P.; Williams, N.L.; McCormick, B.A.
    Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration (2006), Am. J. Physiol. Lung Cell Mol. Physiol., 290, 703-709.
No PubMed abstract available
Search for more literature for 3.1.1.4

Activating Compound

Activating Compound Comment Organism Structure
additional information infection of A549 cells with PAO1 resulted in a 13.6-fold increase in the amount of phosphorylated cPLA2 Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
N-(4-amylcinnamoyl) anthranilic acid i.e. 12-hydroperoxy-5Z,8Z,10E,14Zeicosatetraenoic acid Pseudomonas aeruginosa
ONO-RS-082
-
 Pseudomonas aeruginosa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Pseudomonas aeruginosa 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas aeruginosa Pseudomonas aeruginosa PLA2 is involved in induction of polymorphonuclear cell migration across lung epithelial barriers in hosts, e.g. A549 alveolar epithelial cells, mediated by epithelial production of the eicosanoid hepoxilin A3, HXA3, in response to Pseudomonas aeruginosa infection, HXA3 is a polymorphonuclear cell, PMN, chemoattractant metabolized from arachidonic acid, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Pseudomonas aeruginosa PLA2 is involved in induction of polymorphonuclear cell migration across lung epithelial barriers in hosts, e.g. A549 alveolar epithelial cells, mediated by epithelial production of the eicosanoid hepoxilin A3, HXA3, in response to Pseudomonas aeruginosa infection, HXA3 is a polymorphonuclear cell, PMN, chemoattractant metabolized from arachidonic acid, overview Pseudomonas aeruginosa ?
-
 ?

Synonyms

Synonyms Comment Organism
cytosolic PLA2
-
 Pseudomonas aeruginosa
cytotoxin ExoU
-
 Pseudomonas aeruginosa
PLA2
-
 Pseudomonas aeruginosa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Pseudomonas aeruginosa