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Literature summary for 3.1.1.4 extracted from

  • Shin, H.S.; Chin, M.R.; Kim, J.S.; Chung, J.H.; Ryu, C.K.; Jung, S.Y.; Kim, D.K.
    Purification and characterization of a cytosolic, 42-kDa and Ca2+-dependent phospholipase A2 from bovine red blood cells: its involvement in Ca2+-dependent release of arachidonic acid from mammalian red blood cells (2002), J. Biol. Chem., 277, 21086-21094.
    View publication on PubMed
Search for more literature for 3.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
7-chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione competitive inhibitor Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0139
-
 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine pH 7.5 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
cytosol
-
 Bos taurus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 gel filtration Homo sapiens
42000
-
 gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme is responsible for Ca2+-dependent release of arachidonic acid from red blood cells ?
-
 ?
additional information Bos taurus enzyme is responsible for Ca2+-dependent release of arachidonic acid from red blood cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-
erythrocyte
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0056
-
-
 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
-
 Homo sapiens 1-palmitoyl-sn-glycero-3-phosphocholine + palmitic acid
-
 ?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
-
 Bos taurus 1-palmitoyl-sn-glycero-3-phosphocholine + palmitic acid
-
 ?
1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine + H2O
-
 Homo sapiens 1-palmitoyl-sn-glycero-3-phosphocholine + linolic acid
-
 ?
1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine + H2O
-
 Bos taurus 1-palmitoyl-sn-glycero-3-phosphocholine + linolic acid
-
 ?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O preferred substrate Homo sapiens 1-stearoyl-sn-glycero-3-phosphocholine + arachidonic acid
-
 ?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O preferred substrate Bos taurus 1-stearoyl-sn-glycero-3-phosphocholine + arachidonic acid
-
 ?
additional information enzyme is responsible for Ca2+-dependent release of arachidonic acid from red blood cells Homo sapiens ?
-
 ?
additional information enzyme is responsible for Ca2+-dependent release of arachidonic acid from red blood cells Bos taurus ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.13
-
 7-chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione pH 7.5 Bos taurus

pI Value

Organism Comment pI Value Maximum pI Value
Bos taurus isoelectric focusing
-
 3.9