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Literature summary for 3.1.1.4 extracted from

  • Ketelhut, D.F.; de Mello, M.H.; Veronese, E.L.; Esmeraldino, L.E.; Murakami, M.T.; Arni, R.K.; Giglio, J.R.; Cintra, A.C.; Sampaio, S.V.
    Isolation, characterization and biological activity of acidic phospholipase A2 isoforms from Bothrops jararacussu snake venom (2003), Biochimie, 85, 983-991.
    View publication on PubMed
Search for more literature for 3.1.1.4

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method Bothrops jararacussu

Inhibitors

Inhibitors Comment Organism Structure
4-bromophenacyl bromide suppresses anticoagulant activity, indirect haemolytic activity and inhibition of platelet aggregation, does not inhibit the induction of edema Bothrops jararacussu

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bothrops jararacussu SIIISPIIA, SIIISPIIB and SIIISPIIIA show significant anticoagulant activity but no indirect haemolytic activity. SIIISPIIIB shows no anticoagulant activity but presents indirect haemolytic activity. With the exception of SIIISPIIB, which inhibits platelet aggregation, all the others are capable of inducing edema ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bothrops jararacussu
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-
-

Purification (Commentary)

Purification (Comment) Organism
4 isoforms: SIIISPIIA, SIIISPIIB, SIIISPIIIA, SIIISPIIIB Bothrops jararacussu

Source Tissue

Source Tissue Comment Organism Textmining
venom
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 Bothrops jararacussu
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
97
-
 isoform SIIISPIIIB Bothrops jararacussu
270
-
 isoform SIIISPIIIA Bothrops jararacussu
279
-
 isoform SIIISPIIB Bothrops jararacussu
290
-
 isoform SIIISPIIA Bothrops jararacussu

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SIIISPIIA, SIIISPIIB and SIIISPIIIA show significant anticoagulant activity but no indirect haemolytic activity. SIIISPIIIB shows no anticoagulant activity but presents indirect haemolytic activity. With the exception of SIIISPIIB, which inhibits platelet aggregation, all the others are capable of inducing edema Bothrops jararacussu ?
-
 ?

pI Value

Organism Comment pI Value Maximum pI Value
Bothrops jararacussu isoelectric focusing, pH gradient 5-8.5
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 5.3