Literature summary for 3.1.1.4 extracted from

Andriao-Escarso, S.H.; Soares, A.M.; Rodrigues, V.M.; Angulo, Y.; Diaz, C.; Lomonte, B.; Gutierrez, J.M.; Giglio, J.R.
Myotoxic phospholipases A2 in Bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu (2000), Biochimie, 82, 755-763.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-nitrobenzenesulfonyl fluoride	BthTX-I: myotoxic activity reduced to 75% and the cytotoxic activity reduced to 76%	Bothrops spp.
4-bromophenacyl bromide	BthTX-II: loses most of its catalytic, indirect haemolytic, anticoagulant, myotoxic and cytotoxic activity, BthTX-I: myotoxic activity reduced to 50% and the cytotoxic activity reduced to 13%	Bothrops spp.
o-nitrophenylsulfonyl chloride	BthTX-I: myotoxic activity reduced to 65% and the cytotoxic activity reduced to 58%	Bothrops spp.
Rose bengal	BthTX-I: myotoxic activity reduced to 20% and the cytotoxic activity reduced to 0.5%	Bothrops spp.

Organism

Organism	UniProt	Comment	Textmining
Bothrops spp.	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
venom	-	Bothrops spp.	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	BthTX-I has no enzymatic activity	Bothrops spp.
37.08	-	BthTX-II	Bothrops spp.

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme has indirect haemolytic, anticoagulant, myotoxic and cytotoxic activity	Bothrops spp.	?	-	?

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Release 2023.1 (January 2023)