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Literature summary for 3.1.1.4 extracted from
- Phospholipase A2 activity on mixed lipid monolayers: Activation of phospholipase A2 from porcine pancreas and Crotalus adamanteus by anionic and neutral amphophiles (1981), Arch. Biochem. Biophys., 212, 508-514.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 3,5-Dibromosalicylate | enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2 | Sus scrofa |  |
| 3,5-Dibromosalicylate | enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2 | Crotalus adamanteus | |
| 3,5-diiodosalicylate | enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2 | Sus scrofa | |
| 3,5-diiodosalicylate | enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2 | Crotalus adamanteus | |
| Acetyl salicylate | enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2 | Sus scrofa | |
| Acetyl salicylate | enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2 | Crotalus adamanteus | |
| Dicetyl phosphate | enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2 | Sus scrofa | |
| Dicetyl phosphate | enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2 | Crotalus adamanteus | |
| salicylic acid | enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2 | Sus scrofa | |
| salicylic acid | enhanced enzyme penetration, activation above the normal cutoff pressure of PLA2 | Crotalus adamanteus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,2-Didecanoin | inhibition below the normal cutoff pressure of PLA2 | Crotalus adamanteus | |
| 1,2-Didecanoin | inhibition below the normal cutoff pressure of PLA2 | Sus scrofa | |
| 3,5-Dibromosalicylate | inhibition below the normal cutoff pressure of PLA2 | Crotalus adamanteus | |
| 3,5-Dibromosalicylate | inhibition below the normal cutoff pressure of PLA2 | Sus scrofa | |
| 3,5-diiodosalicylate | inhibition below the normal cutoff pressure of PLA2 | Crotalus adamanteus | |
| 3,5-diiodosalicylate | inhibition below the normal cutoff pressure of PLA2 | Sus scrofa | |
| Acetyl salicylate | inhibition below the normal cutoff pressure of PLA2 | Crotalus adamanteus | |
| Acetyl salicylate | inhibition below the normal cutoff pressure of PLA2 | Sus scrofa | |
| Dicetyl phosphate | inhibition below the normal cutoff pressure of PLA2 | Crotalus adamanteus | |
| Dicetyl phosphate | inhibition below the normal cutoff pressure of PLA2 | Sus scrofa | |
| N-dodecyl-N,N-dimethyl-3-aminopropanesulfonate | - |
Sus scrofa | |
| N-tetradecyl-N,N-dimethyl-3-aminopropanesulfonate | - |
Sus scrofa | |
| salicylic acid | inhibition below the normal cutoff pressure of PLA2 | Crotalus adamanteus | |
| salicylic acid | inhibition below the normal cutoff pressure of PLA2 | Sus scrofa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + H2O | Sus scrofa | - |
lysophosphatidylcholine + a fatty acid | - |
? | |
| phosphatidylcholine + H2O | Crotalus adamanteus | - |
lysophosphatidylcholine + a fatty acid | - |
? | |
| phospholipids + H2O | Sus scrofa | - |
? | - |
? | |
| phospholipids + H2O | Crotalus adamanteus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Crotalus adamanteus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreas | - |
Sus scrofa | - |
| venom | - |
Crotalus adamanteus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 1 mg PLA2 per ml | Sus scrofa |
| 4°C, 1 mg PLA2 per ml | Crotalus adamanteus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O | - |
Sus scrofa | 1-decanoyl-sn-glycero-3-phosphocholine + decanoate | - |
? | |
| 1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O | - |
Crotalus adamanteus | 1-decanoyl-sn-glycero-3-phosphocholine + decanoate | - |
? | |
| phosphatidic acid + H2O | - |
Sus scrofa | 1-acylglycerophosphate + fatty acid | - |
? | |
| phosphatidic acid + H2O | - |
Crotalus adamanteus | 1-acylglycerophosphate + fatty acid | - |
? | |
| phosphatidylcholine + H2O | - |
Sus scrofa | 1-acylglycerophosphocholine + fatty acid | - |
? | |
| phosphatidylcholine + H2O | - |
Crotalus adamanteus | 1-acylglycerophosphocholine + fatty acid | - |
? | |
| phosphatidylcholine + H2O | - |
Sus scrofa | lysophosphatidylcholine + a fatty acid | - |
? | |
| phosphatidylcholine + H2O | - |
Crotalus adamanteus | lysophosphatidylcholine + a fatty acid | - |
? | |
| phosphatidylglycerol + H2O | - |
Sus scrofa | 1-acylglycerol + fatty acid | - |
? | |
| phosphatidylglycerol + H2O | - |
Crotalus adamanteus | 1-acylglycerol + fatty acid | - |
? | |
| phospholipids + H2O | - |
Sus scrofa | ? | - |
? | |
| phospholipids + H2O | - |
Crotalus adamanteus | ? | - |
? | |
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