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Literature summary for 3.1.1.4 extracted from
- Hydrolysis of dipalmitoylphosphatidylcholine small unilamellar vesicles by porcine pancreatic phospholipase A2 (1986), J. Biol. Chem., 261, 5328-5333.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | reaction products like palmitoylphosphatidylcholine + palmitic acid do not have an activating effect under all experimental conditions, not essential | Sus scrofa |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2 | - |
1,2-dipalmitoyl-phosphatidylcholine, small unilamellar vesicles | 25.6°C | Sus scrofa |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | PLA2-binding is Ca2+-independent, PLA2-activation requires Ca2+ | Sus scrofa |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phospholipids + H2O | Sus scrofa | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreas | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-dipalmitoyl-phosphatidylcholine + H2O | - |
Sus scrofa | 1-palmitoyl-glycerophosphorylcholine + palmitic acid | - |
? | |
| 1,2-dipalmitoyl-phosphatidylcholine + H2O | 1,2-dipalmitoyl-phosphatidylcholine, small unilamellar vesicles | Sus scrofa | 1-palmitoyl-glycerophosphocholine + palmitic acid | - |
? | |
| phospholipids + H2O | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | Sus scrofa | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.917 | - |
1,2-dipalmitoyl-phosphatidylcholine | small unilamellar vesicles | Sus scrofa | |
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