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Literature summary for 3.1.1.4 extracted from
- Localization and characterization of phospholipase A2 in mouse mammary gland-derived cells (1991), Arch. Biochem. Biophys., 286, 293-299.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate | - |
Mus musculus |  |
| Nonidet-P40 | - |
Mus musculus | |
| sodium deoxycholate | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | cells harvested in EGTA | Mus musculus | 5737 | - |
| plasma membrane | cells harvested in buffer containing free Ca2+ | Mus musculus | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | Ca2+-dependent association with cellular membranes | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phospholipids + H2O | Mus musculus | eicosanoids | ? | - |
? | |
| phospholipids + H2O | Mus musculus | cancer | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast adenocarcinoma cell | - |
Mus musculus | - |
| mammary gland | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-acyl-2-arachidonoyl-sn-glycerophosphocholine + H2O | - |
Mus musculus | 1-acyl-sn-glycerophosphocholine + arachidonic acid | - |
? | |
| 1-acyl-2-arachidonoyl-sn-glycerophosphoethanolamine + H2O | - |
Mus musculus | 1-acyl-sn-glycerophosphoethanolamine + arachidonic acid | - |
? | |
| 1-acyl-2-linoleoyl-sn-glycerophosphocholine + H2O | - |
Mus musculus | 1-acyl-sn-glycerophosphocholine + linoleic acid | - |
? | |
| 1-acyl-2-oleoyl-sn-glycerophosphocholine + H2O | - |
Mus musculus | 1-acyl-sn-glycerophosphocholine + oleic acid | - |
? | |
| 1-acyl-2-palmitoyl-sn-glycerophosphocholine + H2O | - |
Mus musculus | 1-acyl-sn-glycerophosphocholine + palmitic acid | - |
? | |
| 1-stearoyl-2-arachidonoylphosphatidylcholine + H2O | - |
Mus musculus | 1-stearoyl-glycerophosphorylcholine + arachidonic acid | - |
? | |
| phosphatidylinositol + arachidonic acid | - |
Mus musculus | arachidonoyl phosphatidylinositol + fatty acid | - |
? | |
| phospholipids + H2O | eicosanoids | Mus musculus | ? | - |
? | |
| phospholipids + H2O | cancer | Mus musculus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.1 | - |
substrate: phosphatidylethanolamine, without DTT | Mus musculus |
| 9 | - |
substrate: phosphatidylethanolamine, with DTT | Mus musculus |
| 9.5 | - |
substrate: phosphatidylcholine, without DTT | Mus musculus |
| 9.7 | - |
substrate: phosphatidylcholine, with DTT | Mus musculus |
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