Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.4 extracted from

  • Dessen, A.; Tang, J.; Schmidt, H.; Stahl, M.; Clark, J.D.; Seehra, J.; Somers, W.S.
    Crystal structure of human cytosolic Phospholipase A2 reveals a novel topology and catalytic mechanism (1999), Cell, 97, 349-360.
    View publication on PubMed
Search for more literature for 3.1.1.4

Cloned(Commentary)

Cloned (Comment) Organism
full length human cPLA2, residues 1-749, expressed in E5-CHO-cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ structure of Ca2+-binding site Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phospholipids + H2O Homo sapiens influence on platelet aggregation ?
-
 ?
phospholipids + H2O Homo sapiens inflammatory diseases ?
-
 ?
phospholipids + H2O Homo sapiens release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O cPLA2 cleaves selectively arachidonoyl phospholipids Homo sapiens 1-palmitoyl-glycerophosphorylcholine + arachidonic acid
-
 ?
1-stearoyl-2-arachidonoylphosphatidylcholine + H2O cPLA2 cleaves selectively arachidonoyl containing phospholipids Homo sapiens 1-stearoyl-glycerophosphorylcholine + arachidonic acid
-
 ?
phospholipids + H2O influence on platelet aggregation Homo sapiens ?
-
 ?
phospholipids + H2O inflammatory diseases Homo sapiens ?
-
 ?
phospholipids + H2O release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
monomer cPLA2, no data concerning MW Homo sapiens