Application | Comment | Organism |
---|---|---|
medicine | acidotropic accumulation of cocaine in lysosomes inhibits acid phospholipase A1 and inactivates acid sphingomyelinase, inducing a mixed lysosomal lipidosis | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cocaine | 10 mM, below 10% residual activity | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Rattus norvegicus | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | fibroblast | Rattus norvegicus | - |
fibroblast | cultured cells | Rattus norvegicus | - |