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Literature summary for 3.1.1.3 extracted from

  • Chiu, H.K.; Qian, K.; Ogimoto, K.; Morton, G.J.; Wisse, B.E.; Agrawal, N.; McDonald, T.O.; Schwartz, M.W.; Dichek, H.L.
    Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis (2010), Endocrinology, 151, 993-1001.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.3

Activating Compound

Activating Compound Comment Organism Structure
additional information hepatic lipase activity increases with increased visceral fat Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information hepatic lipase deficiency reduces body fate stores and reduces adipose tissue macrophage content, fully prevents development of hepatic steatosis, and is consistent with reduced inflammation and a lean phenotype, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Mus musculus
-
adipose tissue
-
 Mus musculus
-
liver
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
hepatic lipase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction hepatic lipase deficiency reduces body fate stores and protects against diet-induced obesity Mus musculus
physiological function hepatic lipase-mediated lipoprotein hydrolysis provides free fatty acids for energy, storage, and nutrient signaling and may play a role in energy homeostasis. The enzyme activity favors weight gain and obesity Mus musculus