Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CGI-58 | a ATGL activator protein | Mus musculus | |
CGI-58 | a ATGL activator protein, located on the surface of lipid droplets, requires interaction with perilipin A for activation of ATGL. After beta-adrenergic stimulation, CGI-58 disperses into the cytoplasm within min, which appears to be due to phosphorylation of perilipin A. Phosphorylation at Ser517 of perilipin A is mandatory for stimulated lipolysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | ATGL-/- mice are obese, exhibit impaired thermogenesis, oxidize more carbohydrate, and die prematurely due to cardiac dysfunction | Homo sapiens |
additional information | ATGL-/- mice are obese, exhibit impaired thermogenesis, oxidize more carbohydrate, and die prematurely due to cardiac dysfunction. ATGL-/- mice developed heart failure due to myocardial fibrosis and a mechanical contraction defect, thereby reducing their life span. HSL-/- mice show defective beta-adrenergic stimulated lipolysis, protection against high-fat diet-induced obesity, and possible impairments in insulin secretion. Phenotypes, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | mainly | Mus musculus | 5737 | - |
cytoplasm | mainly | Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | adipose TG lipase, ATGL, and hormone sensitive lipase, HSL, regulate lipolysis in a serial manner, with ATGL cleaving the first fatty acid and HSL the second fatty acid of triacylglycerol, lipolysis control, detailed overview | ? | - |
? | |
additional information | Mus musculus | ATGL and hormone sensitive lipase, HSL, regulate lipolysis in a serial manner, with ATGL cleaving the first fatty acid and HSL the second fatty acid of triacylglycerol, lipolysis control, detailed overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | ATGL is the predominant TG lipase in adipose tissue | Mus musculus | - |
adipose tissue | ATGL is the predominant TG lipase in adipose tissue | Homo sapiens | - |
skeletal muscle | - |
Mus musculus | - |
skeletal muscle | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | adipose TG lipase, ATGL, and hormone sensitive lipase, HSL, regulate lipolysis in a serial manner, with ATGL cleaving the first fatty acid and HSL the second fatty acid of triacylglycerol, lipolysis control, detailed overview | Homo sapiens | ? | - |
? | |
additional information | ATGL and hormone sensitive lipase, HSL, regulate lipolysis in a serial manner, with ATGL cleaving the first fatty acid and HSL the second fatty acid of triacylglycerol, lipolysis control, detailed overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
adipose TG lipase | - |
Mus musculus |
adipose TG lipase | - |
Homo sapiens |
ATGL | - |
Mus musculus |
ATGL | - |
Homo sapiens |
hormone sensitive lipase | - |
Homo sapiens |
HSL | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | adipose TG lipase, ATGL, is the predominant TG lipase in adipose tissue and an important regulator of triacyglycerol degradation in skeletal muscle | Mus musculus |
physiological function | ATGL is a TG hydrolase in skeletal muscle that alters fat metabolism. Adipose TG lipase, ATGL, is the predominant TG lipase in adipose tissue and an important regulator of triacyglycerol degradation in skeletal muscle, overview. ATGL might also possess acylglycerol transacylase activity. Regulation of ATGL transacylation and lipase activities by undefined mechanisms can alter the metabolic balance within adipocytes, from anabolic (i.e. high transacylase activity) to catabolic (i.e. high lipase activity) situations, and thereby alter substrate delivery to peripheral tissues | Homo sapiens |