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Literature summary for 3.1.1.3 extracted from

  • Matsumane, H.; Furui, M.; Shibatani, T.; Tosa, T.
    Production of optically active 3-phenylglycidic acid ester by the lipase from Serratia marcescens in a hollow-fiber membrane reactor (1994), J. Ferment. Bioeng., 78, 59-63.
No PubMed abstract available

Application

Application Comment Organism
synthesis production of (2R,3S)-3-(4-methoxyphenyl)glycidic acid methyl ester, which is an intermediate in the synthesis of diltiazem. diltiazem hydrochloride is a coronary vasodilator and a calcium channel blocker Serratia marcescens

Organism

Organism UniProt Comment Textmining
Serratia marcescens
-
Sr41 8000
-
Serratia marcescens Sr41 8000
-
Sr41 8000
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(4-methoxyphenyl)glycidic acid methyl ester + H2O
-
Serratia marcescens (2R,3S)-3-(4-methoxyphenyl)glycidic acid methyl ester + (2S,3R)-3-(4-methoxyphenyl)glycidic acid + methanol
-
?
3-(4-methoxyphenyl)glycidic acid methyl ester + H2O
-
Serratia marcescens Sr41 8000 (2R,3S)-3-(4-methoxyphenyl)glycidic acid methyl ester + (2S,3R)-3-(4-methoxyphenyl)glycidic acid + methanol
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
-
Serratia marcescens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Serratia marcescens