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Literature summary for 3.1.1.29 extracted from

  • Vivanco-Dominguez, S.; Cruz-Vera, L.R.; Guarneros, G.
    Excess of charged tRNALys maintains low levels of peptidyl-tRNA hydrolase in pth(Ts) mutants at a non-permissive temperature (2006), Nucleic Acids Res., 34, 1564-1570.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information excess of charged tRNALys maintains low levels of peptidyl-tRNA hydrolase in pth mutants at a non-permissive temperature, strain AA7852 phenotype and levels of aminoacyl- and peptidyl-tRNAs, overproduction of tRNALys suppresses the effects of pthTs mutation at 41°C but not at 43°C, and increases the levels of aminoacyl-tRNA, overview Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidyl-tRNALys + H2O Escherichia coli accumulation of peptidyl-tRNA due to enzyme misfunction is toxic to the cells, overproduction of tRNALys suppresses the effects of pthTs mutation at 41°C but not at 43°C, and increases the levels of aminoacyl-tRNA peptide + tRNALys
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?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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mutant strain AA7852 with temperature-sensitive Pth, gene pthTs
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Source Tissue

Source Tissue Comment Organism Textmining
additional information mutant strain AA7852 with temperature-sensitive Pth grown at 32°C and at 41°C Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl-tRNALys + H2O
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Escherichia coli peptide + tRNALys
-
?
peptidyl-tRNALys + H2O accumulation of peptidyl-tRNA due to enzyme misfunction is toxic to the cells, overproduction of tRNALys suppresses the effects of pthTs mutation at 41°C but not at 43°C, and increases the levels of aminoacyl-tRNA Escherichia coli peptide + tRNALys
-
?

Synonyms

Synonyms Comment Organism
peptidyl-tRNA hydrolase
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Escherichia coli
PTH
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Escherichia coli