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Literature summary for 3.1.1.2 extracted from

  • Hofmann, J.; Keifer, M.; Furlong, C.; De Roos, A.; Farin, F.; Fenske, R.; van Belle, G.; Checkoway, H.
    Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-Exposed agricultural pesticide handlers (2009), Environ. Health Perspect., 117, 1402-1408.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.2

Application

Application Comment Organism
medicine biologic monitoring for AREase status among pesticide handlers may be warranted to identify individuals who are at particularly high risk of organophosphate-related health effect Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phenyl acetate + H2O
-
 Homo sapiens phenol + acetate
-
 ?

Synonyms

Synonyms Comment Organism
AREase
-
 Homo sapiens
arylesterase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function low AREase catalytic efficiency (i.e., the Q192 alloform for chlorpyrifos oxon hydrolysis) and low plasma AREase activity are associated with butyrylcholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers. Q192R genotype modifies the relation between plasma AREase activity and butyrylcholinesterase inhibition Homo sapiens